静脉栓塞和术后出血是细胞减灭手术与热浸润腹腔化疗（HIPEC）的并发症。此系统综述的目的是总结现有的关于细胞减灭手术与HIPEC对10天手术后凝血和纤溶作用的影响的知识。2022年12月12日在PubMed、Embase和Web of Science筛选出研究。提取术前到术后10天内凝血和纤溶生物标志物的数据。在15个研究中，有13项研究报告了原发性止血标志物。11项研究发现细胞减灭手术和HIPEC后血小板计数减少，而两项研究报告了血小板功能减弱。12项研究报告，细胞减灭手术和HIPEC后在术后10天内出现了继发性止血不良，表现为国际标准化比率、凝血酶原时间和活化部分凝血活酶时间延长。3项研究报告纤维蛋白原从术前到术后第3天出现下降，但随后到术后第10天增加。与此相符，3项研究发现在第一天术后出现了凝块强度下降，最大振幅和最大凝块硬度也下降，这表明了止血受损。4项研究发现在术后10天内D-二聚体、第VIII因子和凝血酶生成量均有所增加。4项研究研究了细胞减灭手术和HIPEC后的纤溶作用，用ROTEM/TEG和纤溶酶原激活剂抑制剂-1 (PAI-1)进行了检测，结果是相互矛盾的。总之，在细胞减灭手术和HIPEC后血小板计数减少，继发性止血发生细微改变。关于细胞减灭手术和HIPEC对纤溶作用的影响数据稀少，需要进一步研究。Thieme版权所有。

Venous thromboembolism and postoperative bleeding are complications of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). The aim of this systematic review was to summarize current knowledge on the effect of cytoreductive surgery with HIPEC on coagulation and fibrinolysis within 10 days after surgery. Studies were identified in PubMed, Embase, and Web of Science on December 12, 2022. Data on biomarkers of coagulation and fibrinolysis measured preoperatively up to the 10th postoperative day were extracted. Among 15 included studies, 13 studies reported markers of primary hemostasis. Eleven studies found reduced platelet count following cytoreductive surgery with HIPEC and two studies reported reduced platelet function. Twelve studies reported impaired secondary hemostasis until postoperative day 10 indicated by prolonged international normalized ratio, prothrombin time, and activated partial thromboplastin time. Fibrinogen was decreased in three studies from preoperative to postoperative day 3 switching to increased levels until postoperative day 10. In accordance, three studies found reduced maximum amplitude and maximum clot firmness by thromboelastography/thromboelastometry (ROTEM/TEG) on the first postoperative day indicating impaired clot strength. Four studies demonstrated increased d-dimer, factor (F) VIII, and thrombin generation during the 10 postoperative days. Four studies investigated fibrinolysis by ROTEM/TEG and plasminogen activator inhibitor-1 (PAI-1) after cytoreductive surgery with HIPEC reporting contradictive results. In conclusion, a decrease in platelet count and subtle changes in secondary hemostasis were found following cytoreductive surgery with HIPEC. Data on the effect of cytoreductive surgery with HIPEC on fibrinolysis are sparse and this needs to be further investigated.Thieme. All rights reserved.