乳房密度是一个强有力的，潜在可调整的乳腺癌危险因素。我们关于乳房密度的几乎所有知识都来自于乳腺X线摄影术，因此，关于40岁以下的年轻女性的乳房密度知之甚少。本研究检验了两种备选乳房密度测量方法——光学乳房光谱（OBS）和双能X线吸收测量法（DXA）在年龄在18-40岁的女性中的可接受性和表现。使用OBS测量了539名年龄在18-40岁的女性的乳房组织成分（百分比水分、胶原含量和脂肪含量）。对于169名女性的子集，也通过DXA测量了乳房密度（纤维腺密集体积（%FGV），绝对密集体积（FGV）和非密集体积（NFGV））。使用调整后的经过验证的问卷评估了测量程序的可接受性。通过检查这些测量值之间的相关性和一些已知的决定乳腺X线摄影术乳房密度的因素的关系来评估它们的表现。超过93% 的参与者认为OBS和DXA是可以接受的。OBS-%水分和胶原和%FGV之间的相关性为0.48。年龄和体重指数与OBS-%水分和胶原和%FGV成反比，与OBS-%脂肪和NFGV成正比。OBS和DXA为年龄在18-40岁的年轻女性测量乳房密度提供了可接受和可行的替代方法。©2023. 作者。

Breast density is a strong and potentially modifiable breast cancer risk factor. Almost everything we know about breast density has been derived from mammography, and therefore, very little is known about breast density in younger women aged <40. This study examines the acceptability and performance of two alternative breast density measures, Optical Breast Spectroscopy (OBS) and Dual X-ray Absorptiometry (DXA), in women aged 18-40.Breast tissue composition (percent water, collagen, and lipid content) was measured in 539 women aged 18-40 using OBS. For a subset of 169 women, breast density was also measured via DXA (percent fibroglandular dense volume (%FGV), absolute dense volume (FGV), and non-dense volume (NFGV)). Acceptability of the measurement procedures was assessed using an adapted validated questionnaire. Performance was assessed by examining the correlation and agreement between the measures and their associations with known determinants of mammographic breast density.Over 93% of participants deemed OBS and DXA to be acceptable. The correlation between OBS-%water + collagen and %FGV was 0.48. Age and BMI were inversely associated with OBS-%water + collagen and %FGV and positively associated with OBS-%lipid and NFGV.OBS and DXA provide acceptable and viable alternative methods to measure breast density in younger women aged 18-40 years.© 2023. The Author(s).