在癌症患者中已使用不同的幸福感度量。本研究旨在首先探究健康状态效用（HSU）、能力和主观幸福感（SWB）工具在癌症中的敏感性。一个癌症特定的工具（QLQ-C30）被包括在其中，并转化为癌症特定的HSU得分。此外，还考察了解释整体生活满意度的关键生活领域的相对重要性。数据来自多工具比较调查。使用线性回归探索QLQ-C30次量表解释HSU和SWB的程度。采用基于核的正则化最小二乘（KRLS）机器学习方法探索癌症患者的生活领域重要性。正如预期的，QLQ-C30子量表解释了其衍生的癌症特定HSU中大部分的差异（R2 = 0.96），其次是通用HSU工具（R2为0.65-0.73）和SWB和能力工具（R2为0.33-0.48）。由于这些工具的构建，癌症专用测量与通用HSU更为相关，而不是SWB测量。除了健康外，生活成就、人际关系、生活水平和未来安全都在解释癌症患者整体生活满意度方面发挥重要作用。

Different wellbeing measures have been used among cancer patients. This study aimed to first investigate the sensitivity of health state utility (HSU), capability, and subjective wellbeing (SWB) instruments in cancer. A cancer-specific instrument (QLQ-C30) was included and transferred onto the cancer-specific HSU scores. Furthermore, it examined the relative importance of key life domains explaining overall life satisfaction. Data were drawn from the Multi-instrument Comparison survey. Linear regression was used to explore the extent to which the QLQ-C30 sub-scales explain HSU and SWB. Kernel-based Regularized Least Squares (KRLS), a machine learning method, was used to explore the life domain importance of cancer patients. As expected, the QLQ-C30 sub-scales explained the vast majority of the variance in its derived cancer-specific HSU (R2 = 0.96), followed by generic HSU instruments (R2 of 0.65-0.73) and SWB and capability instruments (R2 of 0.33-0.48). The cancer-specific measure was more closely correlated with generic HSU than SWB measures, owing to the construction of these instruments. In addition to health, life achievements, relationships, the standard of living, and future security all play an important role in explaining the overall life satisfaction of cancer patients.