本研究旨在探讨在软组织肉瘤（STS）患者中，静脉血栓栓塞事件（VTEs）是否是肺转移疾病的临床相关预测因子。在这项回顾性队列分析中，我们纳入了2002年1月至2020年1月间，接受软组织肉瘤手术治疗的患者。感兴趣的主要结果是非转移性STS诊断后的肺转移发展情况。收集肿瘤深度、阶段、手术干预类型、化疗、放疗、身体质量指数和吸烟情况。还获取了在STS诊断后发生的VTE事件，包括深静脉血栓、肺栓塞和其他血栓栓塞事件。使用单变量分析和多变量 logistic 回归来确定潜在的肺转移预测因子。 我们纳入了319名年龄为54.9±16岁的患者。37名患者（11.6%）在STS诊断后患有VTE，54名（16.9%）出现了肺转移。单变量筛查显示肺转移、术前和术后化疗、吸烟史以及手术后VTE可能是肺转移的预测因子。多变量 logistic 回归分析显示吸烟史 [概率比（OR）2.0，置信区间（CI）1.1-3.9，P=0.04] 和VTE（OR 6.3，CI 2.9-13.6，P < 0.001）是预测STS肺转移的独立危险因素，在单变量筛查中考虑年龄、性别、肿瘤阶段和神经血管侵犯因素进行调整。 在STS诊断后患有VTE的患者与没有静脉血栓栓塞事件的患者相比，发展转移性肺疾病的概率比为6.3。吸烟史也与未来的肺转移有关。©2023年。外科肿瘤学会。

This study aimed to investigate whether venous thromboembolic events (VTEs) are clinically relevant predictors of pulmonary metastatic disease in patients with soft tissue sarcomas (STSs).In this retrospective cohort analysis, we included patients with STS surgically treated for sarcoma between January 2002 and January 2020. The primary outcome of interest was development of pulmonary metastasis after non-metastatic STS diagnosis. Tumor depth, stage, type of surgical intervention, chemotherapy, radiation therapy, body mass index, and smoking status were collected. Episodes of VTEs following STS diagnosis, including deep vein thrombosis, pulmonary embolism, and other thromboembolic events, were also obtained. Univariate analyses and multivariable logistic regression were used to identify potential predictors for pulmonary metastasis.We included 319 patients with mean age of 54.9 ± 16 years. Thirty-seven patients (11.6%) had VTE after STS diagnosis, and 54 (16.9%) developed pulmonary metastasis. Univariate screening revealed pulmonary metastasis, pre- and postoperative chemotherapy, smoking history, and VTE after surgery as potential predictors of pulmonary metastasis. Multivariable logistic regression revealed smoking history [odds ratio (OR) 2.0, confidence interval (CI) 1.1-3.9, P = 0.04] and VTE (OR 6.3, CI 2.9-13.6, P < 0.001) as independent risk factors for predicting pulmonary metastasis in patients with STS, after adjusting for the factors in the univariate screening as well as age, sex, stage of the tumor, and neurovascular invasion.Patients with VTE after STS diagnosis have an odds ratio of 6.3 for developing metastatic pulmonary disease compared with patients without venous thromboembolic events. Smoking history was also associated with future pulmonary metastases.© 2023. Society of Surgical Oncology.