从毛果瘤果树枝中分离出10种未描述的多肽类苯甲酰基邻苯三酚衍生物（Garcowacinols A-J）（1-10）和四种已知类似物（11-14）。通过光谱学数据分析（1D和2D NMR和HRESIMS），确定它们的结构，并根据NOESY和ECD数据确定它们的绝对构型。通过MTT比色法对所有分离出的化合物进行了对五种人类癌细胞（KB，HeLa S3，MCF-7，Hep G2和HT-29）以及Vero细胞的细胞毒性评估。 Garcowacinol C对所有五种癌细胞表现出显著的活性，其IC50值在0.61-9.50μM的范围内。在KB细胞，Garcowacinol F和7-epiclusianone以及Guttiferone Q向MCF-7细胞观察到了选择性增殖抑制，其IC50值小于10μM。版权所有©2023。由Elsevier Ltd.出版。

Ten undescribed polyprenylated benzoylphloroglucinol derivatives named garcowacinols A‒J (1-10) and four known analogues (11-14) were isolated from the twigs of Garcinia cowa. Their structures were determined by spectroscopic data analysis (1D and 2D NMR and HRESIMS), and their absolute configurations were established based on NOESY and ECD data. All isolated compounds were evaluated for their cytotoxicity against five types of human cancer cells (KB, HeLa S3, MCF-7, Hep G2, and HT-29) as well as Vero cells by MTT colorimetric assay. Garcowacinol C was significantly active against all the five cancer cells with IC50 values in the range of 0.61-9.50 μM. Selective proliferative inhibitions were observed on garcowacinol F and 7-epiclusianone against KB cells, and guttiferone Q toward MCF-7 cells with IC50 values less than 10 μM.Copyright © 2023. Published by Elsevier Ltd.