乳腺癌（BC）是女性第二常见的癌症和死亡原因。最近许多研究调查了长链非编码RNA（lncRNA）作为新型遗传因素对BC风险、生存、临床和病理特征的关联。最近的研究还调查了二甲双胍治疗2型糖尿病（T2D）作为一线治疗在lncRNA表达/调节或BC发病率、结果、死亡率和生存方面所起的作用。这项综合研究旨在回顾与BC特征相关的lncRNA，并确定二甲双胍调控的lncRNA及其在BC或其他类型癌症中的作用机制。最后，本文描述了二甲双胍通过调节包括GAS5、HOTAIR、MALAT1和H19在内的五个与BC相关的lncRNA来影响BC，并描述了本文中所描述的几种分子机制。此外，本文还描述了二甲双胍通过调节包括AC006160.1、Loc100506691、lncRNA-AF085935、SNHG7、HULC、UCA1、H19、MALAT1、AFAP1-AS1和AC026904.1在内的十个lncRNA来调节其他类型癌症的作用。©2023年作者。

Breast cancer (BC) is the second most common cancer and cause of death in women. In recent years many studies investigated the association of long non-coding RNAs (lncRNAs), as novel genetic factors, on BC risk, survival, clinical and pathological features. Recent studies also investigated the roles of metformin treatment as the firstline treatment for type 2 diabetes (T2D) played in lncRNAs expression/regulation or BC incidence, outcome, mortality and survival, separately. This comprehensive study aimed to review lncRNAs associated with BC features and identify metformin-regulated lncRNAs and their mechanisms of action on BC or other types of cancers. Finally, metformin affects BC by regulating five BC-associated lncRNAs including GAS5, HOTAIR, MALAT1, and H19, by several molecular mechanisms have been described in this review. In addition, metformin action on other types of cancers by regulating ten lncRNAs including AC006160.1, Loc100506691, lncRNA-AF085935, SNHG7, HULC, UCA1, H19, MALAT1, AFAP1-AS1, AC026904.1 is described.© 2023. The Author(s).