研究动态
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卵巢癌中外泌体的诊断和治疗前景。

The Diagnostic and Therapeutic Prospects of Exosomes in Ovarian Cancer.

发表日期:2023 Feb 28
作者: Qianrun Chen, Jiayan Shi, Danhua Ruan, Ce Bian
来源: Bjog-Int J Obstet Gy

摘要:

Exosomes是源自内体系统的纳米级囊泡,参与了许多生物和病理过程。新兴证据表明,具有细胞特异性成分的exosomes与卵巢癌的发生和进展有关。因此,源自卵巢癌的exosomes可能成为潜在的诊断生物标志物和治疗靶点。在本文中,我们简要介绍了exosomes的生物学特性和最新的分离和检测技术。此外,我们总结了exosomes在卵巢癌中的许多功能,希望为临床应用exosomes在卵巢癌的诊断和治疗中提供理论支持。本文受版权保护。版权所有。
Exosomes are nano-sized vesicles derived from the endosomal system and involved in many biological and pathological processes. Emerging evidence has demonstrated that exosomes with cell-specific constituents are associated with the tumorigenesis and progression of ovarian cancer. Therefore, exosomes derived from ovarian cancers can be potential diagnostic biomarkers and therapeutic targets. In this review, we briefly present the biological characteristics of exosomes and the recent advances in isolating and detecting exosomes. Furthermore, we summarize the many functions of exosomes in ovarian cancer, hoping to provide a theoretical basis for clinical applications of exosomes in the diagnosis and treatment of ovarian cancer.This article is protected by copyright. All rights reserved.