什么是癌症代谢?
What is cancer metabolism?
发表日期:2023 Feb 22
作者:
Lydia W S Finley
来源:
BIOMASS & BIOENERGY
摘要:
营养素的摄取和代谢支持基本的细胞过程,从生物能量学到生物量生产和细胞命运调节。虽然许多细胞代谢研究聚焦于癌细胞,但是在癌细胞中澄清的代谢原理适用于广泛的哺乳动物细胞。本综述的目的是讨论癌症代谢学领域如何为揭示细胞代谢原理和分解允许细胞满足其特定需求的代谢网络提供框架,从而了解特定于上下文的代谢偏好和责任将会解锁以改善患者护理为目的的新方法来靶向癌细胞。 版权所有©2023 Elsevier Inc.。保留所有权利。
The uptake and metabolism of nutrients support fundamental cellular process from bioenergetics to biomass production and cell fate regulation. While many studies of cell metabolism focus on cancer cells, the principles of metabolism elucidated in cancer cells apply to a wide range of mammalian cells. The goal of this review is to discuss how the field of cancer metabolism provides a framework for revealing principles of cell metabolism and for dissecting the metabolic networks that allow cells to meet their specific demands. Understanding context-specific metabolic preferences and liabilities will unlock new approaches to target cancer cells to improve patient care.Copyright © 2023 Elsevier Inc. All rights reserved.