姜黄素:一种天然有机成分,在卵巢癌中发挥多方面作用。
Curcumin: a natural organic component that plays a multi-faceted role in ovarian cancer.
发表日期:2023 Mar 01
作者:
Xiaoping Liu, Mingming Qi, Xidie Li, Jingjin Wang, Mingyuan Wang
来源:
ANTIOXIDANTS & REDOX SIGNALING
摘要:
来自姜黄根茎的天然有机成分姜黄素具有丰富的抗肿瘤、抗氧化和抗炎症药理活性等特点,其中抗肿瘤活性尤其引起了世界各地学者的广泛关注。大量研究表明,姜黄素可以延缓卵巢癌(OC)的发展,增加其对化疗的敏感性,并减少化疗药物的副作用。促进细胞凋亡、抑制细胞周期进展、诱导自噬、抑制肿瘤转移和调节酶活性等作用表明了它具有显著的抗癌潜力。通过深入研究姜黄素抗OC机制,其临床应用将拥有更广阔的前景。本综述总结了有关姜黄素抗OC活性的最新研究,并讨论了具体机制,希望为进一步研究和应用提供参考。©2023.作者等。
Curcumin, a natural organic component obtained from Curcuma longa's rhizomes, shows abundant anti-tumor, antioxidant and anti-inflammatory pharmacological activities, among others. Notably the anti-tumor activity has aroused widespread attention from scholars worldwide. Numerous studies have reported that curcumin can delay ovarian cancer (OC), increase its sensitivity to chemotherapy, and reduce chemotherapy drugs' side effects. It has been shown considerable anticancer potential by promoting cell apoptosis, suppressing cell cycle progression, inducing autophagy, inhibiting tumor metastasis, and regulating enzyme activity. With an in-depth study of curcumin's anti-OC mechanism, its clinical application will have broader prospects. This review summarizes the latest studies on curcumin's anti-OC activities, and discusses the specific mechanism, hoping to provide references for further research and applications.© 2023. The Author(s).