前列腺癌是全球老年人健康的严重威胁。患者生存时间和生活质量一旦发生转移就会急剧下降。因此，在发达国家，对前列腺癌进行早期筛查非常先进。所采用的检测方法包括前列腺特异性抗原（PSA）检测和直肠指诊。然而，在一些发展中国家中，早期筛查的普及率不高，导致患有转移性前列腺癌的患者数量增加。此外，转移性和局部性前列腺癌的治疗方法有很大区别。在许多患者中，早期前列腺癌细胞往往会转移，这是由于延迟观察、阴性PSA结果和治疗时间的延迟引起的。因此，鉴定易于转移的患者对于未来的临床研究非常重要。本文介绍了许多与前列腺癌转移相关的预测分子。这些分子涉及肿瘤细胞基因的突变和调控、肿瘤微环境的变化和液体活检。在接下来的十年中，PSMA PET/CT和液体活检将成为极好的预测工具，而177Lu-PSMA-RLT在转移性前列腺癌患者中显示出极佳的抗肿瘤效果。

Prostate cancer is a serious threat to the health of older adults worldwide. The quality of life and survival time of patients sharply decline once metastasis occurs. Thus, early screening for prostate cancer is very advanced in developed countries. The detection methods used include Prostate-specific antigen (PSA) detection and digital rectal examination. However, the lack of universal access to early screening in some developing countries has resulted in an increased number of patients presenting with metastatic prostate cancer. In addition, the treatment methods for metastatic and localized prostate cancer are considerably different. In many patients, early-stage prostate cancer cells often metastasize due to delayed observation, negative PSA results, and delay in treatment time. Therefore, the identification of patients who are prone to metastasis is important for future clinical studies.this review introduced a large number of predictive molecules related to prostate cancer metastasis. These molecules involve the mutation and regulation of tumor cell genes, changes in the tumor microenvironment, and the liquid biopsy.In next decade, PSMA PET/CT and liquid biopsy will be the excellent predicting tools, while 177Lu- PSMA-RLT will be showed excellent anti-tumor efficacy in mPCa patients.