线粒体是细胞内能量生产的主要来源，支持组织的代谢需求。功能失调的线粒体涉及各种疾病，从神经退行性到癌症等。因此，调节功能失调的线粒体为线粒体功能障碍疾病提供了新的治疗机会。天然产物是多效性的、易获取的治疗剂的来源，具有广阔的在新药研发中的前景。近年来，许多针对线粒体的天然产物得到了广泛研究，并在调节线粒体功能失调方面展现了有希望的药理活性。因此，我们总结了针对线粒体的天然产物的最新研究进展，并讨论了天然产物在调节线粒体功能失调方面的机制，包括调节线粒体质量控制系统和调节线粒体功能。此外，我们还描述了发展针对线粒体的天然产物的未来前景和挑战，并强调了天然产物在处理线粒体功能障碍方面的潜在价值。版权所有©2023年Chen、Ruan、Shi、Du和Bian。

Mitochondria are the primary source of energy production in cells, supporting the metabolic demand of tissue. The dysfunctional mitochondria are implicated in various diseases ranging from neurodegeneration to cancer. Therefore, regulating dysfunctional mitochondria offers a new therapeutic opportunity for diseases with mitochondrial dysfunction. Natural products are pleiotropic and readily obtainable sources of therapeutic agents, which have broad prospects in new drug discovery. Recently, many mitochondria-targeting natural products have been extensively studied and have shown promising pharmacological activity in regulating mitochondrial dysfunction. Hence, we summarize recent advances in natural products in targeting mitochondria and regulating mitochondrial dysfunction in this review. We discuss natural products in terms of their mechanisms on mitochondrial dysfunction, including modulating mitochondrial quality control system and regulating mitochondrial functions. In addition, we describe the future perspective and challenges in the development of mitochondria-targeting natural products, emphasizing the potential value of natural products in mitochondrial dysfunction.Copyright © 2023 Chen, Ruan, Shi, Du and Bian.