那不勒斯评分是一种新的预后评分，根据炎症和营养状况进行开发，并经常应用于癌症患者。本研究旨在评估使用那不勒斯预后评分（NPS）来预测急性ST段抬高型心肌梗死（STEMI）后左心室射血分数（LVEF）下降的发展。该研究采用多中心与回顾性设计，包括2280名于2017年至2022年间接受原发性经皮冠状动脉介入治疗（pPCI）的STEMI患者。所有参与者根据其NPS分为2组。评估了这两组与LVEF之间的关系。低那不勒斯风险组（组1）包括799名患者，而高那不勒斯风险组（组2）则有1481名患者。与组1相比，组2的住院死亡率、休克率和无复流率均较高（P＜0.001，P = 0.032，P = 0.004）。NPS与出院LVEF显著呈负相关（B系数：-1.51，95％ CI-2.26；-0.76，P = 0.001）。NPS是一个简单且易于计算的风险评分，可以帮助鉴定高风险STEMI患者。据我们所知，本研究是首个证明LVEF和NPS之间关系的。

The Naples score is a new prognostic score developed according to inflammatory and nutritional status and frequently evaluated in cancer patients. The present study aimed to evaluate using the Naples prognostic score (NPS) to predict the development of decreased left ventricular ejection fraction (LVEF) after acute ST-segment elevation myocardial infarction (STEMI). The study has a multicenter and retrospective design and included 2280 patients with STEMI who underwent primary percutaneous coronary intervention (pPCI) between 2017 and 2022. All participants were divided into 2 groups according to their NPS. The relationship between these 2 groups and LVEF was evaluated. The low-Naples risk group (Group-1) included 799 patients, and the high-Naples risk group (Group-2) had 1481 patients. Hospital mortality, shock, and no-reflow rates were found to be higher in Group 2 compared with Group 1 (P < .001, P = .032, P = .004). The NPS was significantly inversely associated with discharge LVEF (B coefficient: -1.51, 95% CI-2.26; -.76, P = .001). NPS, a simple and easily calculated risk score, may help identify high-risk STEMI patients. To the best of our knowledge, the present study is the first to demonstrate the relationship between low LVEF and NPS in patients with STEMI.