研究动态
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坚持不懈是关键:提高免疫疗法响应预测。

Persistence is key: Refining immunotherapy response prediction.

发表日期:2023 Mar 14
作者: Michelle Leung, Nicholas McGranahan
来源: IMMUNITY

摘要:

肿瘤突变负荷(TMB)是一种被证明的、但不完美的免疫检查点阻断(ICB)反应预测因子。最近在《自然·医学》上,Niknafs等人证明,持续的突变负担是TMB的一个子集,是预测患者ICB治疗结果的改进指标。版权所有©2023 Elsevier Inc. 发布。
Tumor mutation burden (TMB) is a proven, but imperfect, immune checkpoint blockade (ICB) response-predictor. Recently in Nature Medicine, Niknafs et al. demonstrate that persistent mutation burden, a subset of TMB, is an improved metric to predict patient ICB therapy outcome.Copyright © 2023. Published by Elsevier Inc.