癌相关性血栓（CAT）是癌症患者导致发病率和死亡率的主要原因。虽然血小板计数被研究作为各种情况下CAT的预测因子，但关于血小板激活参数的知识很匮乏。本文提供了一个可用文献对成人癌症患者动脉和静脉血栓与血小板计数和/或功能之间的关联进行系统评价和Meta分析的研究。该评价是根据PRISMA（系统评价和Meta分析的推荐报告要求）声明进行的。 PubMed和Embase检索了截至2022年3月的文献。国家心脏，肺和血液研究所的工具用于质量评估。总共包括研究100篇，其中调查了实体癌（n = 61），血液系统癌（n = 17）或混合类型癌（n = 22）患者的CAT和血小板计数（n = 90），血小板指数（n = 19）和血小板功能/激活标记（n = 13）之间的关联。八十一项研究以静脉血栓作为其结果指标，而4项研究以动脉血栓为其结果指标，15项研究同时具有动脉和静脉血栓。我们发现，高血小板计数的血栓风险比为1.50（95％置信区间：1.19-1.88）。我们看到平均血小板体积和可溶性P选择素等血小板激活标记与动脉和静脉血栓有关联的趋势。只有一项研究使用流式细胞术研究了动态血小板功能。总之，血小板计数在不同癌症类型和环境下与CAT有关。血小板功能或激活标记分析可能有助于协助对癌症患者血栓风险评估，但迄今为止研究很少。保留所有权利。

Cancer-associated thrombosis (CAT) is a major cause of both morbidity and mortality in cancer patients. Platelet count has been investigated as a predictor of CAT in various settings while knowledge on platelet activation parameters is sparse. This report provides a systematic review and meta-analysis on available literature on associations between platelet count and/or function and arterial and venous thrombosis in adult cancer patients. The review was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. PubMed and Embase were searched up to March 2022. The National Heart, Lung, and Blood Institute's tools were used for quality assessment. In total, 100 studies were included which investigated the association between CAT and platelet count (n = 90), platelet indices (n = 19), and platelet function/activation markers (n = 13) in patients with solid cancers (n = 61), hematological cancers (n = 17), or mixed cancer types (n = 22). Eighty-one studies had venous thrombosis as their outcome measure, while 4 had arterial thrombosis and 15 studies had both. We found significantly elevated odds ratio of 1.50 (95% confidence interval: 1.19-1.88) for thrombosis with higher platelet counts. We saw a tendency toward an association between markers of platelet activation in forms of mean platelet volume and soluble P selectin and both arterial and venous thrombosis. Only one study investigated dynamic platelet function using flow cytometry. In conclusion, platelet count is associated with CAT across different cancer types and settings. Platelet function or activation marker analysis may be valuable in assisting thrombosis risk assessment in cancer patients but is sparsely investigated so far.Thieme. All rights reserved.