细胞迁移是多细胞生物发育和稳态的关键生理过程；这个复杂系统中的错误可能会触发癌症或炎症性疾病的发展。因此，调节细胞迁移提供了药物发现的机会。肽正在全球治疗市场上变得越来越重要，因为与已经确立的小分子药物或生物制剂相比，它们具有独特的特性。在本文中，我们鉴定了超过470种调节细胞迁移的肽，并分析了它们的特点。其中95%以上的肽处于发现或临床前阶段，因为肽药物的转化往往导致药物开发过程中的瓶颈。我们总结了在(临床前)临床开发中增强生物活性肽药物属性的化学策略。版权所有©2023作者。由Elsevier Ltd.出版。保留所有权利。

Cell migration is a key physiological process in the development and homeostasis of multicellular organisms; errors in this complex system can trigger the development of cancer or inflammatory disorders. Therefore, modulating cell migration provides opportunities for drug discovery. Peptides are gaining importance on the global therapeutics market, given their unique properties compared with established small-molecule drugs or biologics. In this review, we identified over 470 peptides modulating cell migration and analyzed their characteristics. Over 95% of these peptides are in the discovery or preclinical stage, because the transition of peptide hits into a drug leads often results in a bottleneck in the development process. We summarize chemical strategies in (pre-)clinical development to enhance drug-like properties of bioactive peptides.Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.