在本研究中，基于巯基乙酸修饰的铋纳米片制备了一种新的，可远程控制的药物递送、放射敏化和光热疗法剂。采用低能量（400瓦）超声波辐射结合NaBH4和Tween 20制备了铋纳米片，2小时内完成合成。所得纳米片的大小为40-60纳米，厚度为1-3原子层。通过透射电子显微镜，高分辨率透射电子显微镜，X射线衍射，拉曼光谱和紫外光谱对纳米片的形态和结构特性进行了研究。纳米片表面经过巯基乙酸修饰，从而增强了Mitomycin C药物的载荷能力，可避免因提高静电相互作用而引发的药物爆发释放。在pH值分别为7.4和5.0的条件下，药物释放量分别从45.1％增加到69.8％。在1064 nm激光照射下，巯基乙酸修饰的铋纳米片具有51.4％的光热转换效率，可在5分钟内使100μg/ml的溶液温度升高24.9°C。药物递送，光热疗法和放射敏化的联合作用通过细胞凋亡大大损伤了MDA-MB-231细胞并减少其形成的菌落。版权所有©2023，由Elsevier B.V.出版。

In current study, a new remotely controlled drug delivery, radio-sensitizing, and photothermal therapy agent based on thioglycolic acid modified bismuth nanosheets is thoroughly evaluated. Bismuth nanosheets were synthesized using sodium borohydride (NaBH4) and Tween 20 through low energy (400 W) sonication within 2 h. The resultant nanosheets were 40-60 nm in size and 1-3 atomic layers in thickness. The morphological and structural characteristics of the nanosheets were studied using transmission electron microscopy, high-resolution transmission electron microscopy, X-ray diffraction, Raman spectroscopy and ultraviolet spectroscopy. The surface of the nanosheets was modified using thioglycolic acid, which resulted in enhanced Mitomycin C loading capacity to 274.35% and circumvented the burst drug release due to the improved electrostatic interactions. At pH 7.4 and 5.0, the drug release was significantly boosted from 45.1 to 69.8%, respectively. Thioglycolic acid modified bismuth nanosheets under 1064 nm laser irradiation possessed photothermal conversion efficiency of η=51.4% enabling a temperature rise of 24.9 °C at 100 μg/ml in 5 min. The combination of drug delivery, photothermal therapy, and radio-sensitization greatly damaged the MDA-MB-231 cells through apoptosis and diminished their colony forming.Copyright © 2023. Published by Elsevier B.V.