大量次生代谢物已从拥有约700种物种的鼠尾草属中分离出来，并在世界范围内被用于药典。鼠尾草制剂的多种生物学性质已被报道，包括抗氧化、抗微生物、降压、抗高血糖、抗高脂血症、抗癌和皮肤愈合。富含多酚的鼠尾草黄杆鼠尾草Boiss.根和地上部提取物对胃病原菌幽门螺杆菌（Hp）具有杀菌作用，并减少Hp脂多糖（LPS）对胃上皮细胞造成的有害影响。本研究旨在研究S. cadmica提取物对通过 Hp LPS vs 标准 LPS 大肠杆菌(Ec)质子霉素极化巨噬细胞 及细胞因子和吞噬功能的影响，这些指标在Hp感染期间受到影响。使用 LPS Hp/Ec 和/或 S. cadmica 提取物刺激的 THP-1 人单核细胞的巨噬细胞表面标志物、细胞质或可溶性标志物和吞噬能力进行检测。使用豚鼠的骨髓巨噬细胞确定 Hp 的吞噬。THP-1 细胞（24h）与 LPS Hp/Ec 刺激后极化为 M1 巨噬细胞，激活核因子 kappa B、分泌肿瘤坏死因子（TNF）α、白细胞介素（IL）1 beta、巨噬细胞趋化蛋白 (MCP) -1、免疫调节剂 IL-10 和产生反应性氧化物。这些作用在细胞使用 S. cadmica 提取物后减弱。暴露于研究提取物的 THP-1 巨噬细胞表现出增强的吞噬功能，伴随 CD11b/CD11d 表达升高和诱导型一氧化氮合酶的增强产生。它们还增加了骨髓巨噬细胞对Hp的吞噬。这些作用与全局DNA甲基化无关。S. cadmica 提取物具有免疫调节活性，可能在控制 Hp LPS 驱动的巨噬细胞活性方面有用。版权所有©2023 Elsevier B.V.发表。

The large number of secondary derivatives have been isolated from the genus Salvia with about 700 species, and used in the pharmacopoeias throughout the world. Various biological properties of Salvia formulations have been reported including as antioxidant, antimicrobial, hypotensive, anti-hyperglycemia, anti-hyperlipidemia, anti-cancer, and skin curative. Salvia cadmica Boiss. root and aerial part extracts enriched with polyphenols are bactericidal towards gastric pathogen Helicobacter pylori (Hp) and diminish deleterious effects induced by Hp lipopolysaccharide (LPS) towards gastric epithelial cells.To examine the influence of S. cadmica extracts on the M1/M2 polarization of macrophages primed with Hp LPS vs standard LPS Escherichia coli (Ec), and the macrophage cytokine as well as phagocytic activity, which are affected during Hp infection.Macrophages derived from THP-1 human monocytes primed with LPS Hp/Ec and/or S. cadmica extracts, were examined for the biomarkers of activation (surface, cytoplasmic or soluble), and phagocytic capacity. The bone marrow macrophages of Caviae porcellus were used to determine the engulfment of Hp.Priming of THP-1 cells (24h) with LPS Hp/Ec resulted in polarization of M1 macrophages, activation of nuclear factor kappa B, secretion of tumor necrosis factor (TNF)-α, interleukin (IL)-1 beta, macrophage chemotactic protein (MCP)-1, immunoregulatory IL-10, and production of reactive oxygen species. These effects were diminished after restimulation of cells with S. cadmica extracts. THP-1 macrophages exposed to studied extracts showed an increased phagocytic capacity, in conjunction with elevated CD11b/CD11d expression and enhanced production of inducible nitric oxide synthase. They also increased Hp engulfment by bone marrow macrophages. These effects were not related to a global DNA methylation.S. cadmica extracts possess an immunomodulating activity, which might be useful in control of H. pylori LPS driven activity of macrophages.Copyright © 2023. Published by Elsevier B.V.