COVID-19大流行对全球医疗保健产生了影响，包括癌症患者SARS-CoV-2感染的高死亡率；患有多发性骨髓瘤（MM）的个体尤其容易出现不良结局。然而，即使对于避免严重感染的MM患者，疫情的影响也是相当大的。必要的社会地理行为适应措施的后果，包括长时间的遮蔽和非疫情医疗服务的中断，尚未被完全理解。利用323个在英国接连诊断出的新诊断的MM患者的真实世界数据集，我们研究了COVID-19大流行对骨髓瘤诊断路径、诊断时疾病阶段和相关临床结果的影响。我们展示了越来越多的MM患者通过紧急服务接受治疗，并且骨质和超髓外疾病的发病率也增加了。在诱导治疗和符合条件的自体干细胞移植参与比例的选择方面也有所不同。虽然紧急患者的生存率统计上较低，但整个在疫情期间被诊断出的队列尚未展示出显著的生存差异，这使得这一群体的长期随访至关重要。这个数据集突出了COVID-19大流行对MM患者产生的广泛问题，而临床医生和政策制定者的完全影响尚需进一步阐明。©2023年。作者。

The COVID-19 pandemic has had global healthcare impacts, including high mortality from SARS-CoV-2 infection in cancer patients; individuals with multiple myeloma (MM) are especially susceptible to poor outcomes. However, even for MM patients who avoided severe infection, the ramifications of the pandemic have been considerable. The consequences of necessary socio-geographical behavior adaptation, including prolonged shielding and interruptions in delivery of non-pandemic medical services are yet to be fully understood. Using a real-world dataset of 323 consecutive newly diagnosed MM patients in England, we investigated the impact of the COVID-19 pandemic on routes to myeloma diagnosis, disease stage at presentation and relevant clinical outcomes. We demonstrate increasing MM presentations via emergency services and increased rates of bony and extra-medullary disease. Differences were seen in choice of induction therapy and the proportion of eligible patients undertaking autologous stem cell transplantation. Whilst survival was statistically inferior for emergency presentations, significant survival differences have yet to be demonstrated for the entire cohort diagnosed during the pandemic, making extended follow-up critical in this group. This dataset highlights wide-ranging issues facing MM patients consequent of the COVID-19 pandemic, with full impacts for clinicians and policy-makers yet to be elucidated.© 2023. The Author(s).