胶质母细胞瘤（GBM）是一种恶性程度最高的星形细胞瘤，主要侵犯大脑半球和大脑皮质。它是一种致命和难治的实体肿瘤，成人的5年生存率仅为5％。 IL6 / JAK / STAT3是参与GBM发病和进展的重要信号通路。GBM组织中STAT3的表达显著高于正常脑细胞。 STAT3的异常激活使GBM的肿瘤微环境处于免疫抑制状态。此外，阻断STAT3通路可以有效抑制GBM的生长和转移。在此基础上，抑制STAT3可能是GBM的新治疗方法，而靶向STAT3治疗和常规治疗的结合可能会改善GBM治疗的现状。本综述总结了STAT3在GBM发病中的作用以及STAT3用于GBM靶向治疗的可行性。版权所有©2023 Fu，Hou，Dong和Hou。

Glioblastoma (GBM) is the most malignant of astrocytomas mainly involving the cerebral hemispheres and the cerebral cortex. It is one of the fatal and refractory solid tumors, with a 5-year survival rate of merely 5% among the adults. IL6/JAK/STAT3 is an important signaling pathway involved in the pathogenesis and progression of GBM. The expression of STAT3 in GBM tissues is substantially higher than that of normal brain cells. The abnormal activation of STAT3 renders the tumor microenvironment of GBM immunosuppression. Besides, blocking the STAT3 pathway can effectively inhibit the growth and metastasis of GBM. On this basis, inhibition of STAT3 may be a new therapeutic approach for GBM, and the combination of STAT3 targeted therapy and conventional therapies may improve the current status of GBM treatment. This review summarized the roles of STAT3 in the pathogenesis of GBM and the feasibility of STAT3 for GBM target therapy.Copyright © 2023 Fu, Hou, Dong and Hou.