酗酒和慢性饮酒会导致酒精性肝病（ALD）的进展，这是全球发病率和死亡率的主要原因。ALD包括简单脂肪肝、酒精性脂肪性肝炎（ASH）、纤维化、酒精性肝硬化和肝细胞癌（HCC）等病理生理谱系。乙醛脱氢酶（ALDH2）是最重要的酶，可以将乙醛转化为醋酸，并高水平地表达于肝脏、肾脏、肌肉和心脏。ALDH2*2等位基因在东亚人群中的发生率高达40％，对酒精代谢产生显著影响。有趣的是，许多研究表明，ALDH2缺陷的个体在饮酒后更容易患上肝炎症。此外，越来越多的证据表明，ALDH2缺陷与肝脏、胃、结肠和肺癌的发展存在关联。异黄酮类似物是源于植物的低分子量化合物，类似哺乳动物体内雌激素的结构和活性，被称为植物雌激素。最近的研究报告表明，异黄酮类似物对ALD进展具有益处。本篇综述总结了异黄酮类似物在ALD中的作用及其在肝脏病理生理学治疗中的潜力。特别是，我们强调了计算方法在这一领域的重要性。版权©2023 Lee 和 Kim。

Excessive and chronic alcohol intake can lead to the progression of alcoholic liver disease (ALD), which is a major cause of morbidity and mortality worldwide. ALD encompasses a pathophysiological spectrum such as simple steatosis, alcoholic steatohepatitis (ASH), fibrosis, alcoholic cirrhosis, and hepatocellular carcinoma (HCC). Aldehyde dehydrogenase (ALDH2) is the most vital enzyme that produces acetate from acetaldehyde and is expressed at high levels in the liver, kidneys, muscles, and heart. The ALDH2*2 allele is found in up to 40% of East Asian populations, and has a significant impact on alcohol metabolism. Interestingly, several studies have shown that individuals with ALDH2 deficiency are more susceptible to liver inflammation after drinking alcohol. Furthermore, there is growing evidence of an association between ALDH2 deficiency and the development of cancers in the liver, stomach, colon, and lung. Isoflavone analogues are low molecular-weight compounds derived from plants, similar in structure and activity to estrogen in mammals, known as phytoestrogens. Recent studies have reported that isoflavone analogues have beneficial effects on the progression of ALD. This mini-review summarizes the current knowledge about the roles of isoflavone analogues in ALD and discusses the therapeutic potential of isoflavone analogues in liver pathophysiology. In particular, we highlight the significance of computational approaches in this field.Copyright © 2023 Lee and Kim.