一种新型的非凋亡性、铁依赖性细胞死亡方式被称为铁死亡，是由脂质过氧化引发的。已证明，许多病理过程包括神经毒性、神经疾病、缺血再灌注损伤，特别是癌症，都受铁死亡调节网络改变的影响。最近的研究已经证实铁死亡在癌症发展和对标准化疗放疗的耐药进化中所扮演的关键作用，因此，建议铁死亡可能是癌症治疗中可行的治疗策略。长链非编码RNA（lncRNA）可以调控基因表达的转录和转录后水平，已在肿瘤发生中得到证实并参与了铁死亡的生物过程，这为调节铁死亡提供了一种有趣的替代治疗方法来治疗癌症。尽管有证据表明，lncRNA在癌细胞的铁死亡中具有机械作用，但是对这些lncRNA的机制和潜在治疗仍缺乏研究。我们解释了lncRNA如何在癌症中调节铁死亡的潜在机制，并检查了将lncRNA作为新型治疗靶标的前景和挑战。 ©2023 Wiley Periodicals LLC.

A novel kind of nonapoptotic, iron-dependent cell death brought on by lipid peroxidation is known as ferroptosis. Numerous pathological processes, including neurotoxicity, neurological disorders, ischemia-reperfusion damage, and particularly cancer, have been demonstrated to be influenced by changes in the ferroptosis-regulating network. Recent studies have established the critical roles that ferroptosis can play in cancer development and the evolution of resistance to standard chemoradiotherapy, thus suggesting that ferroptosis may be a feasible therapeutic strategy for cancer management. Gene expression may be regulated at the transcriptional and posttranscriptional levels by long noncoding RNAs (lncRNAs). They have been implicated in tumorigenesis. Some lncRNAs participate in the biological process of ferroptosis, which represents an exciting alternative to regulate ferroptosis as a means of cancer therapy. Even though there is evidence that lncRNAs have a mechanistic role in the ferroptosis of cancer cells, research on the mechanism and potential treatments for these lncRNAs is still lacking. We elucidate the potential mechanisms by which lncRNAs modulate ferroptosis in cancer and examine the promise and challenges of employing lncRNAs as novel therapeutic targets in cancer.© 2023 Wiley Periodicals LLC.