越来越多的关注已经被关注在子宫内膜癌（EC）患者的生存上，但是EC患者非癌症死因的报道很少。本研究主要旨在调查EC患者的非癌症死因。该研究收集了2000年至2015年在监测、流行病学和终结结果（SEER）计划中被诊断为子宫内膜恶性肿瘤的患者的相关数据，包括年龄、肿瘤分期和治疗方式。我们分析了标准化死亡率（SMR）以确定死因。该研究纳入了135,831名EC患者。随访期间，46,604名（34.3％）患者死亡，其中42.9％、15.6％和41.5％的患者分别死于EC、其他癌症和非癌症原因。随着诊断时间的增加，EC相关死亡人数逐渐减少。最常见的非癌症死因是心脏病、脑血管疾病和糖尿病。与美国总体人口相比，EC患者死亡原因为心脏病（SMR：1.06；95％置信区间[CI]：1.03-1.09）、糖尿病（SMR：1.56；95％CI：1.47-1.65）和败血症（SMR：1.40；95％CI：1.28-1.52），具有统计学意义。对于EC患者，非癌症死亡（主要是心脏病、脑血管疾病和糖尿病）的死亡人数相当于EC患者的死亡人数。此外，与总体人口相比，EC幸存者从败血症和糖尿病死亡的风险更高。这些发现支持幸存者如何避免未来相关的健康风险。通过这样做，临床医生可以提高EC患者的生活质量和生存机会。©2023 The Authors. Cancer Medicine published by John Wiley＆Sons Ltd.

Increasing attention has been paid to the survival of endometrial cancer (EC) patients, but the non-cancer causes of death from EC are rarely reported. This study primarily aimed to investigate the non-cancer causes of death in patients with EC.The study collected relevant data, including age, tumour stage and treatment mode, on patients diagnosed with endometrial malignancies from 2000 to 2015 in the Surveillance, Epidemiology, and End Results (SEER) Programme. We analysed the standardised mortality ratio (SMR) to determine the cause of death.The study included 135,831 patients with EC. During the follow-up, 46,604 (34.3%) patients died, of whom 42.9%, 15.6% and 41.5% died of EC, other cancers and non-cancer causes, respectively. As the diagnosis time increased, the number of EC-associated mortalities gradually decreased. The most common non-cancer causes of death were heart disease, cerebrovascular disease and diabetes. Regarding the general population of the United States, patients with EC died of heart disease (SMR: 1.06; 95% confidence interval [CI]: 1.03-1.09), diabetes (SMR: 1.56; 95% CI: 1.47-1.65) and septicaemia (SMR: 1.40; 95% CI: 1.28-1.52), which were statistically significant.For patients with EC, the number of deaths from non-cancer causes (mainly heart disease, cerebrovascular disease and diabetes mellitus) is equivalent to that of EC. In addition, compared with the general population, EC survivors have a higher risk of death from sepsis and diabetes. These discoveries support how survivors can avoid future-related health risks. By doing this, clinicians can improve the quality of life and chances of the survival of patients with EC.© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.