胃肠道癌症是影响人类的最常见癌症类型。各种不同肿瘤中 HOTAIR，一种 lncRNA 的高表达可能与预后不良有关。在这项研究中，我们对 HOTAIR 表达与胃肠癌之间的关系进行了 Meta 分析。我们全面检索了五个数据库，直到 2023 年 1 月的所有文献。此外，基于 TCGA 基因表达矩阵对六种胃肠癌类型进行共表达分析，预测了 HOTAIR 的靶基因。最后，我们系统地审查了 HOTAIR 如何影响消化系统肿瘤的机制。我们的结果表明，高 HOTAIR 表达组的结果更差，合并风险比（HR）为 1.56（95% CI = 1.38-1.75，P <0.001）。此外，HOTAIR 在食管癌（ESCA）和胃癌（GC）的总生存率中被确定为不利的预后因子，因为 HR 分别为 1.94 和 1.58。HOTAIR 的表达与 HOXC 家族基因之间的高相关性，相关系数分别为 0.863（HOXC11）、0.664（HOXC10）、0.645（HOXC8）和 0.581（HOXC12）。 KEGG 分析显示，'细胞周期' 途径和与感染相关的途径，即 '单纯疱疹病毒 1 感染' 和 '补体和凝血级联反应' 显著富集。此外，我们进行了系统回顾，总结了 HOTAIR 相关的致癌机制。总之，HOTAIR 被确定为潜在的胃肠癌患者预后因子。版权所有 2023 年的作者。

Gastrointestinal cancers are the most common type of cancer affecting humans. High expression of HOTAIR, a lncRNA, in various types of different tumors may be associated with poor prognosis. In this study, we performed a meta-analysis of the relationship between HOTAIR expression and gastrointestinal cancers. Five databases were comprehensively searched for all literature until January 2023. Moreover, the target genes of HOTAIR were predicted by co-expression analysis based on the TCGA gene expression matrix for six gastrointestinal cancer types. Finally, the mechanism through which HOTAIR affects tumors of the digestive system was systematically reviewed. Our results showed that the high HOTAIR expression group had worse outcomes with a pooled hazard ratio (HR) of 1.56 (95% CI = 1.38-1.75, P < 0.001). Furthermore, HOTAIR was identified as an unfavorable prognostic factor for overall survival in the esophageal carcinoma (ESCA) and gastric cancer (GC), as the HR were 1.94 and 1.58, respectively. The high correlation between the expression of HOXC family genes and HOTAIR, with correlation coefficients of 0.863 (HOXC11), 0.664 (HOXC10), 0.645 (HOXC8), and 0.581 (HOXC12). The 'cell cycle' pathway and pathways relating to infections, namely 'herpes simplex virus 1 infection' and 'complement and coagulation cascades' were significantly enriched in KEGG analysis. Also, we perform a systematic review to summarize the related oncogenic mechanism of HOTAIR. In conclusion, the HOTAIR has been identified as a potential prognostic factor in patients with gastrointestinal cancers.Copyright 2023 The Author(s).