配有取代基的三吡啶或四-2-吡啶基吡嗪配体的银配合物已经制备并进行了结构表征。尽管这种配体具有与DNA结合的能力并可将金属的性质与之结合，但使用这种类型配体的银配合物的抗癌属性研究很少。在这里，研究了这些衍生物的抗增殖活性、稳定性、CT-DNA结合和细胞死亡机制。观察到针对不同肿瘤细胞的高细胞毒性，并且更为重要的是，在某些化合物中检测到了肿瘤细胞和健康T淋巴细胞之间的很大的选择性指数。CT-DNA相互作用研究表明，这些衍生物能够通过适度的插层作用与CT-DNA相互作用。此外，细胞死亡研究表明，这些衍生物通过线粒体途径促进细胞凋亡。©2023 Wiley-VCH GmbH。

Silver complexes bearing substituted terpyridine or tetra-2-pyridinylpyrazine ligands have been prepared and structurally characterised. The study of the anticancer properties of silver complexes with this type of ligands is scarce, despite the possibilities of combining the properties of the metal and the ability of the ligands for DNA binding. Here, the antiproliferative activity, stability, CT-DNA binding and mechanism of cell death of these types of derivatives are studied. High cytotoxicity against different tumour cells was observed, and, more important, a great selectivity index has been detected between tumour cells and healthy Lymphocytes T for some of these compounds. The CT-DNA interaction study has shown that these derivatives are be able to interact with CT-DNA via moderate intercalation. Furthermore, cell death studies indicate that these derivatives promote the apoptosis via mitochondrial pathway.© 2023 Wiley-VCH GmbH.