在这项研究中，我们基于肿瘤的CT图像构建了一个三维肿瘤模型，并对磁性纳米颗粒的超热疗法进行了模拟。第一步，我们使用相同的参数在肿瘤组织的两个点注射了磁性纳米颗粒。结果表明，由于血管毛细血管的存在，注射点周围的温度分布并不相似。因此，我们研究了在两个注射点使用不同注射参数对肿瘤热损伤模式和热损伤度影响的情况。结果表明，使用不同的注射参数，如注射速率、注射时间和纳米流体体积分数，可以实现更高的肿瘤细胞损伤度，但异步注射策略并不能导致更显著的肿瘤损伤。所有情况下都没有显著改善温度分布的均匀性，这说明在相同条件下进行注射是创建几乎均匀的温度轮廓的最佳方式。数值模拟验证结果也证明了本研究所使用模型的准确性。这项研究可以作为未来研究设计参数的指南。版权所有©2023 Elsevier Ltd。

In this study, simulation of magnetic nanoparticle hyperthermia is performed on a 3D tumor model constructed based on a CT image of a tumor. In the first step, magnetic nanoparticles are injected into two points of the tumor tissue with the same parameters. Results show that temperature profiles in the vicinity of the injection points are not similar due to the presence of blood capillaries. Therefore, the effects of using dissimilar injection parameters for the two injection points on the heating pattern and damage fraction of the tumor are investigated. The results demonstrate that using dissimilar values for injection parameters such as injection rate, injection time, and nanofluid volume fraction is a way to achieve a higher damage fraction of the tumor cells, but, the asynchronous injections strategy does not lead to more significant damage to the tumor. None of the cases showed significant improvement in the uniformity of the temperature distribution, suggesting that conducting injections under the same conditions is the best way to create an almost uniform temperature profile. The numerical simulation validation results also advocate the accuracy of the model used in this study. This research can serve as a guide for designing parameters for future studies.Copyright © 2023 Elsevier Ltd. All rights reserved.