非恶性脑膜瘤（NM）是美国最常见的脑肿瘤，占非恶性脑肿瘤的54％。本研究旨在调查NM患者死因及其可能与人口统计因素相关的影响因素。我们使用监测、流行病学和结果（SEER）数据库，分析了2004年至2018年间诊断的116,430名NM患者。共观察到31,640例死亡。非肿瘤疾病占所有死亡的63.9％。在这些非肿瘤死亡中，我们发现最常见的死因是心脏疾病（占死亡的18.7％）、脑血管疾病（占死亡的7.4％）和阿尔茨海默病（占死亡的4.5％）。另一方面，癌症占死亡的27.4％，而原位和良性肿瘤占死亡的仅有8.7％。这是首个针对NM患者死因的美国人群研究。我们发现非肿瘤疾病占绝大多数死亡原因。心脏疾病、脑血管疾病、糖尿病和阿尔茨海默病引起的死亡风险显著升高。这些数据可以帮助改善NM患者的生存结果，特别是在考虑人口风险因素的情况下。版权所有©2023 Elsevier Inc.。保留所有权利。

Nonmalignant meningioma (NM) is the most common brain tumor in the United States (US), accounting for 54% of nonmalignant brain tumors. This study aims to investigate the causes of death (CODs) in NM patients and their possible associations with demographic factors.Using the Surveillance, Epidemiology, and End Results (SEER) database, we analyzed 116,430 NM patients diagnosed between the years 2004 and 2018.A total of 31,640 deaths were observed. Non-tumor diseases accounted for 63.9% of all deaths. Out of these non-tumor deaths, we found the most common causes were heart disease (18.7% of deaths), cerebrovascular disease (7.4% of deaths), and Alzheimer's disease (4.5% of deaths). On the other hand, cancer was responsible for 27.4% of deaths, while in-situ and benign tumor deaths accounted for only 8.7%.This is the first US population-based study to investigate the causes of death in NM patients. We found that non-tumor diseases accounted for the majority of deaths. The risks of mortalities caused by heart disease, cerebrovascular disease, diabetes, and Alzheimer's disease were significantly elevated. These data can help improve survival outcomes for NM patients, particularly if adjusted by demographic risk factors.Copyright © 2023 Elsevier Inc. All rights reserved.