纳米技术整合卵巢癌转移治疗：从转移机制到治疗策略的管理路线洞见。
Nanotechnology-integrated ovarian cancer metastasis therapy: Insights from the metastatic mechanisms into administration routes and therapy strategies.
发表日期：2023 Mar 14
作者：
Yu Huang, Chaoqun Li, Xiao Zhang, Meng Zhang, Yidan Ma, Dongxu Qin, Sangsang Tang, Weidong Fei, Jiale Qin
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS
摘要：
卵巢癌是一种恶性肿瘤，位于盆腔，并在早期没有典型的临床症状。大多数患者在晚期被诊断出来，其中约60％患者已经有了腹腔内癌细胞扩散的情况。高复发率和死亡率严重破坏了女性的生殖需求和健康。虽然最近治疗方案和其他辅助疗法取得了进展，改善了卵巢癌的总体生存率，但克服转移仍然是一个挑战，对于实现卵巢癌的治愈是必要的。为了提出抑制卵巢转移的潜在靶点和新策略以及在转移后治疗卵巢癌的方法，本文的第一部分全面解释了卵巢癌的转移机制。纳米医学不仅限于药物输送，还为转移性卵巢癌治疗提供了机会。本文的第二部分强调了纳米药物在转移性卵巢癌治疗中的各种管理途径的优势。此外，本文的第三部分集中介绍了基于卵巢癌转移机制的纳米技术综合治疗转移性卵巢癌的进展。最后，评估了纳米治疗用于卵巢癌转移治疗面临的挑战和前景。总的来说，重点使用基于纳米技术的策略提供了未来改善转移性卵巢癌预后的途径。Copyright © 2023 Elsevier B.V. All rights reserved.
Ovarian cancer is a kind of malignant tumour which locates in the pelvic cavity without typical clinical symptoms in the early stages. Most patients are diagnosed in the late stage while about 60% of them have suffered from the cancer cells spreading in the abdominal cavity. The high recurrence rate and mortality seriously damage the reproductive needs and health of women. Although recent advances in therapeutic regimes and other adjuvant therapies improved the overall survival of ovarian cancer, overcoming metastasis has still been a challenge and is necessary for achieving cure of ovarian cancer. To present potential targets and new strategies for curbing the occurrence of ovarian metastasis and the treatment of ovarian cancer after metastasis, the first section of this paper explained the metastatic mechanisms of ovarian cancer comprehensively. Nanomedicine, not limited to drug delivery, offers opportunities for metastatic ovarian cancer therapy. The second section of this paper emphasized the advantages of various administration routes of nanodrugs in metastatic ovarian cancer therapy. Furthermore, the third section of this paper focuses on advances in nanotechnology-integrated strategies for targeting metastatic ovarian cancer based on the metastatic mechanisms of ovarian cancer. Finally, the challenges and prospects of nanotherapeutics for ovarian cancer metastasis therapy were evaluated. In general, the greatest emphasis on using nanotechnology-based strategies provides avenues for improving metastatic ovarian cancer outcomes in the future.Copyright © 2023 Elsevier B.V. All rights reserved.