来源于患者的人类诱导多能干细胞（iPSCs）可成为研究疾病病理学和治疗学的潜在有用资源。在这项研究中，我们使用仙台病毒从正常成纤维细胞中生成了来自乳腺癌患者的KRIBBi009-A-iPSC系，该系表达多能标志物并通过体外分化和体内畸胎瘤鉴定展现了跨越3种胚层的分化能力。已确认其核型正常，且细胞系无交叉污染。因此，充分发展的iPSC系已被证实适合用于各种研究。版权所有©2023作者。由Elsevier B.V.出版。保留所有权利。

Patient-derived human induced pluripotent stem cells (iPSCs) provide a potentially useful resource for studying disease pathology and therapeutics. In this study, we generated the breast cancer patient-derived KRIBBi009-A-iPSC line from normal fibroblasts using the Sendai virus, which expressed pluripotent markers and exhibited differentiation capacity across 3 germ layers through in vitro differentiation and in vivo teratoma assay. A normal karyotype and the absence of cross-contamination of the cell lines were confirmed. Consequently, the developed iPSC line has been confirmed to be suitable for use in various studies.Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.