Connexin 43在牙胚和良性牙源性肿瘤中的表达。
Connexin 43 expression in tooth germ and benign odontogenic tumors.
发表日期：2023 Feb 01
作者：
Felipe Martins Silveira, Nelly Molina-Frechero, Sandra López-Verdín, Natalia González Umpiérrez, Marcelo Gómez Palacio-Gastellum, Oscar Almeda-Ojeda, Rogelio González-González, Manoela Domingues Martins, Estefania Sicco, Vanesa Pereira-Prado, Ronell Bologna-Molina
来源：
MOLECULAR & CELLULAR PROTEOMICS
摘要：
本研究旨在研究和比较电连接蛋白43 (Cx43) 在牙胚、釉质成纤维瘤、釉质成纤维-牙骨质瘤和常规釉细胞瘤中的免疫组织化学表达。通过免疫组织化学评估了9个牙胚、12个釉质成纤维瘤、12个釉质成纤维-牙骨质瘤和27个釉细胞瘤的Cx43表达情况。大多数牙胚在间充质层(77.6%)和牙齿发生晚期表达Cx43。Cx43在所有组的间充质层中的表达比上皮层高(P < 0.05)，除了釉质成纤维-牙骨质瘤。在分析的不同组的不同层中比较Cx43的表达，发现在上皮层的AFO与AM之间(*P = .0158)和在间充质层的AF与AFO之间(P** = .0046)存在显著差异。本研究结果表明，Cx43是在胚胎和哺牙动物组织中间充质层中表达重要的蛋白。基于牙齿形成组织上皮和间充质层中该蛋白的表达关系，可以推测Cx43参与矿化事件。版权所有©2023 Elsevier Inc.
The aim of this study was to investigate and compare the immunohistochemical expression of connexin 43 (Cx43) in tooth germs (TGs), ameloblastic fibromas (AFs), ameloblastic fibro-odontomas (AFOs), and conventional ameloblastomas (AMs).Nine TGs, 12 AFs, 12 AFOs, and 27 AMs were evaluated for Cx43 expression by immunohistochemistry.Most of the TGs expressed Cx43 in the mesenchyme (77.6%) and in the late stages of odontogenesis. Cx43 was more highly expressed (P < .05) in the mesenchymal layer of all groups than in the epithelial layer except for the AFOs. When comparing the expression of Cx43 in the different layers of the analyzed groups, statistically significant differences were observed between AFO vs AM (*P = .0158) in the epithelial layer and between AF vs AFO (P** = .0046) in the mesenchymal layer.The results obtained in this study showed that Cx43 is a protein with important expression in the mesenchymal layer of the embryonic and odontogenic tissues studied. It could be speculated that Cx43 participates in mineralization events based on the relationship of the expression of this protein between the epithelial and mesenchymal layers of odontogenic tissues.Copyright © 2023 Elsevier Inc. All rights reserved.