背景：先前的研究表明，心率变异性（HRV）分析是化疗诱导心脏毒性的敏感指标。然而，到目前为止，大多数研究都使用长期分析观察长期效应。本研究的主要目的是通过检查短期HRV评估化疗对宫颈癌（CC）患者心脏自主神经系统（ANS）的急性影响。 方法：招募了50名就诊于蚌埠医学院附属第一医院妇产科和肿瘤科的CC患者参加研究。根据化疗方案，将患者分为DC组（多西他赛+卡铂）和TC组（紫杉醇+卡铂）。在化疗前后分别收集了5分钟安静的心电图（ECG），分析了时间域（正常到正常间隔标准偏差（SDNN）和连续差平方根均值（RMSSD））和频率域（低频功率（LF）、高频功率（HF）和（LF / HF））参数，并比较了化疗前后的差异。 结果：结果显示，化疗后的DC组和TC组的SDNN、RMSSD和HF显著高于化疗前（p < 0.05，Cohen's d > 0.5）。此外，TC组的LF在化疗后显著高于化疗前（p < 0.05，Cohen's d > 0.3），而DC组的LF / HF在化疗后显著低于化疗前（p < 0.05，Cohen's d > 0.5）。 结论：紫杉醇和卡铂联合化疗可以在短期内增加CC患者的HRV，HRV可能是化疗诱导心脏ANS扰动的早期敏感工具。Copyright © 2023 Liu，Guan，Sun，Wang，Li，Zhang and Shi。

Background: Previous studies have shown that heart rate variability (HRV) analysis is a sensitive indicator of chemotherapy-induced cardiotoxicity. However, most studies to date have observed long-term effects using long-term analyses. The main purpose of this study was to evaluate the acute effect of chemotherapy on the cardiac autonomic nervous system (ANS) in patients with cervical cancer (CC) by examining short-term HRV. Methods: Fifty patients with CC admitted to the Department of Gynecology and Oncology of the First Affiliated Hospital of Bengbu Medical College were enrolled in the study. Based on their chemotherapy regimens, the patients were divided into a DC group (docetaxel + carboplatin) and a TC group (paclitaxel + carboplatin). A 5-min resting electrocardiogram (ECG) was collected before and the day after chemotherapy: the time domain (standard deviation of normal-to-normal intervals (SDNN) and root mean square of successive differences (RMSSD)) and frequency domain (low-frequency power (LF), high-frequency power (HF), and (LF/HF)) parameters were analyzed, and the differences before and after chemotherapy were compared. Results: The results showed that SDNN, RMSSD and HF were significantly higher in the DC and TC groups after chemotherapy than before (p < 0.05, Cohen's d > 0.5). In addition, LF was significantly higher after TC than before chemotherapy (p < 0.05, Cohen's d > 0.3), and LF/HF was significantly lower after DC than before chemotherapy (p < 0.05, Cohen's d > 0.5). Conclusion: Chemotherapy combining taxane and carboplatin can increase the HRV of CC patients in the short term, and HRV may be a sensitive tool for the early detection of chemotherapy-induced cardiac ANS perturbations.Copyright © 2023 Liu, Guan, Sun, Wang, Li, Zhang and Shi.