颅面畸形（CFDs）通常是由于肿瘤切除、外伤或先天畸形而引起。在全球范围内，外伤是五大死因之一，不同国家的比例各异。因为软组织和硬组织的退化，它们会导致一个无法愈合的组合组织伤口。大约三分之一的口腔疾病是由牙龈疾病引起的。由于该区域的解剖结构复杂，以及对组织的特定要求多种多样，因此CFD治疗面临许多挑战。目前有许多CFDs的治疗方法可供选择，如药物、再生医学（RM）、手术和组织工程学。该新兴科学领域的重点是在外伤或其他慢性疾病后恢复组织或器官的功能。在过去几年中，颅面重建所使用的材料和方法已经显著改进。面部骨折需要尽可能保持骨头完整，因此最初需要移除微小的碎片。由于它们具有优异的骨形成潜力，口腔干细胞可以替换颅面畸形中的骨髓干细胞。本综述文章讨论了不同类型颅面疾病的再生方法。版权所有©2023 Tahmasebi, Mohammadi, Alam, Abbasi, Gharibian Bajestani, Khanmohammad, Haseli, Yazdanian, Esmaeili Fard Barzegar and Tebyaniyan。

Craniofacial deformities (CFDs) develop following oncological resection, trauma, or congenital disorders. Trauma is one of the top five causes of death globally, with rates varying from country to country. They result in a non-healing composite tissue wound as they degenerate in soft or hard tissues. Approximately one-third of oral diseases are caused by gum disease. Due to the complexity of anatomical structures in the region and the variety of tissue-specific requirements, CFD treatments present many challenges. Many treatment methods for CFDs are available today, such as drugs, regenerative medicine (RM), surgery, and tissue engineering. Functional restoration of a tissue or an organ after trauma or other chronic diseases is the focus of this emerging field of science. The materials and methodologies used in craniofacial reconstruction have significantly improved in the last few years. A facial fracture requires bone preservation as much as possible, so tiny fragments are removed initially. It is possible to replace bone marrow stem cells with oral stem cells for CFDs due to their excellent potential for bone formation. This review article discusses regenerative approaches for different types of craniofacial diseases.Copyright © 2023 Tahmasebi, Mohammadi, Alam, Abbasi, Gharibian Bajestani, Khanmohammad, Haseli, Yazdanian, Esmaeili Fard Barzegar and Tebyaniyan.