所有恶性肿瘤中超过25%是消化系统肿瘤（DSTs），其主要包括食管癌，胃癌，胰腺癌，肝癌，胆囊癌和胆管癌，以及结直肠癌。DSTs已成为世界许多国家和地区发病率和死亡率的主要原因，对人类生命和健康构成严重威胁。普通的治疗方法如放射治疗，化疗和手术切除对患者疗效不佳，并且预后不佳。一种称为溶瘤病毒疗法的免疫疗法，最近已经显示出了极好的抗肿瘤效果。在这个领域中一直被广泛研究的病毒之一，即单纯疱疹病毒（HSV），在DSTs中显示出了良好的潜力。通过讨论最近的研究结果，我们概述了HSV在许多DSTs上的治疗效果。此外，我们还讨论了HSV在癌症检测中的重要作用，并展示了一些HSV未来发展的可能性。 版权所有 © 2023 李，李，任，伊，郭和孔。

More than 25% of all malignant tumors are digestive system tumors (DSTs), which mostly include esophageal cancer, gastric cancer, pancreatic cancer, liver cancer, gallbladder cancer and cholangiocarcinoma, and colorectal cancer. DSTs have emerged as one of the prominent reasons of morbidity and death in many nations and areas around the world, posing a serious threat to human life and health. General treatments such as radiotherapy, chemotherapy, and surgical resection can poorly cure the patients and have a bad prognosis. A type of immunotherapy known as oncolytic virus therapy, have recently shown extraordinary anti-tumor effectiveness. One of the viruses that has been the subject of the greatest research in this field, the herpes simplex virus (HSV), has shown excellent potential in DSTs. With a discussion of HSV-1 based on recent studies, we outline the therapeutic effects of HSV on a number of DSTs in this review. Additionally, the critical function of HSV in the detection of cancers is discussed, and some HSV future possibilities are shown.Copyright © 2023 Li, Li, Ren, Yi, Guo and Kong.