本文总结了当前有关不确定潜力克隆造血细胞过度增殖（CHIP）及其与心血管疾病（CVD）和其他结果、发病机制、各种病理学假设机制、现有知识空白、可能的干预目标和治疗意义的相关知识。最近，一种称为CHIP的常见老年血液病被发现是CVD独立的风险因素。CHIP被定义为存在克隆性扩增的血液细胞，涉及白血病诱发性突变，但没有恶性证据。CHIP已知会增加炎症状态，从而增加CVD的风险。除了CVD和恶性肿瘤，CHIP还与肺栓塞、COPD、CKD、卒中、代谢改变、肥胖、肝病和增加总体死亡率有关。与此同时，令人惊讶的是，CHIP在骨髓移植患者中具有积极的结果，并与阿尔茨海默病有类似的相互关系。CVD和癌症的风险随着年龄的增长而增加，这两者是美国的主要死因。CHIP是CVD发展的独立风险因素。大多数CHIP患者的表观遗传调节因子、DNA修复基因或调节酪氨酸激酶等有体细胞突变，但没有明显的血液恶性证据。CHIP预示着白血病发展的风险增加，并在心衰、CAD、MI和不良预后方面携带双倍的CVD风险。CHIP与其他各种病理学有关，使其成为最近几年正在积极研究的领域。目前的研究努力旨在弥合对CHIP理解中仍存在的许多知识空白。 © 2023. 作者（经Springer Science+Business Media LLC的独家许可，隶属于Springer Nature）

This article summarizes the current knowledge about clonal hematopoiesis of indeterminate potential (CHIP), its association with cardiovascular disease (CVD), and other outcomes, pathogenesis, postulated mechanisms of various pathologies, current knowledge gaps, possible targets of intervention, and therapeutic implications.Recently, a common age-related hematological entity known as CHIP has been identified as the independent risk factor for CVD. CHIP is defined as the presence of clonally expanded blood cells involving leukemogenic mutations without the evidence of malignancy. CHIP is known to increase the inflammatory state which in turn is thought to be responsible for increased risk of CVD. Apart from CVD and malignancy, CHIP is also associated with pulmonary embolism, COPD, CKD, stroke, altered metabolism, obesity, liver disease, and increased all-cause mortality. At the same time surprisingly, CHIP is found to have positive outcomes in bone marrow transplant patients and similar reciprocal association with Alzheimer's disease. The risk of CVD and cancer increases with the advancing age, and these two are the leading causes of death in the USA. CHIP is an independent risk factor for CVD development. Most patients with CHIP have somatic clonal mutations in epigenetic regulators, DNA repair genes, or regulatory tyrosine kinases without evidence of overt hematological malignancy. CHIP portends increased risk for leukemia development and carries twofold increased risk of CVD including CAD, MI, and poor prognosis in heart failure. CHIP is associated with various other pathologies making CHIP an area of active research interest in recent years. Current research efforts aim to bridge many knowledge gaps in understanding of CHIP that still exist.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.