非酒精性脂肪性肝病(NAFLD)是一种严重的疾病，会导致肝硬化和肝细胞癌等不良影响。重金属会导致不同的身体器官功能严重受损，包括肝脏。本综述提供了关于重金属暴露与非酒精性脂肪性肝病之间的正负关联的研究。本研究采用系统综述的方法，基于PubMed、Scopus和Science direct数据库搜索脂肪肝、非酒精性脂肪肝、重金属、汞、镉、砷、铬、铊、铅、铁、锌和镍等关键词。共搜索到2200篇文章，经评估筛选后选取28篇。研究发现砷、镉、铁、铅、汞和脂肪肝病之间存在正向关联，而锌和铜与进展性脂肪肝病之间存在负向关系。此外，根据获得的稿件研究了非酒精性脂肪性肝病诊断的实验室方法。在不同的诊断方法中，磁共振成像（MRI）是敏感的方法。©2023年。该作者独家授权给Springer Science+Business Media, LLC,是Springer Nature的一部分。

Non-alcoholic fatty liver disease (NAFLD) is a debilitating disease with adverse effects including cirrhosis and hepatocellular carcinoma. Heavy metals can cause severe dysfunction in different body organs including the liver. This review offers the study regarding the positive or negative association between heavy metals exposure and non-alcoholic fatty liver disease. The method used in this study is a systematic review based on searching in the PubMed, Scopus, and Science direct databases with the keywords of fatty liver, non-alcohol fatty liver, heavy metal, mercury, cadmium, arsenic, chromium, thallium, lead, iron, zinc, and nickel. There were 2200 articles searched in databases, and after assessment, 28 articles were selected. Positive association is established between arsenic, cadmium, iron, lead, mercury, and fatty liver disease. A negative relationship is found between zinc, copper, and progressive fatty liver disease. Furthermore, laboratory methods for NAFLD diagnosis were examined according to the obtained manuscripts. Among the different diagnostic methods, magnetic resonance imaging (MRI) is a sensitive method.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.