胰腺是一种具有内分泌和外分泌功能的腹部器官，胰腺疾病患者会遭受巨大的痛苦。胰腺内各种细胞的规律性细胞死亡被认为在疾病发展中起着关键作用。作为一种新发现的规律性细胞死亡模式，铁死亡有着研究多种疾病的治疗应用潜力。虽然铁死亡已被发现在多种胰腺疾病中出现，但其在胰腺疾病中的作用尚未被系统阐明或评估。了解胰腺不同细胞类型损伤后铁死亡在各种胰腺疾病中的发生至关重要，这有助于确定疾病进展、评估靶向治疗并预测疾病预后。在此，我们总结了铁死亡在急性胰腺炎、慢性胰腺炎、胰管腺癌和糖尿病等四种常见胰腺疾病中的研究进展。此外，阐明铁死亡在少见胰腺疾病中的作用未来有望带来社会效益。© 2023年。作者（独家授权给）日本人类细胞学会。

The pancreas is an abdominal organ with both endocrine and exocrine functions, and patients with pancreatic diseases suffer tremendously. The regulated cell death of various cells in the pancreas is thought to play a key role in disease development. As one of the newly discovered regulated cell death modalities, ferroptosis has the potential for therapeutic applications in the study of multiple diseases. Ferroptosis has been observed in several pancreatic diseases, but its role in pancreatic diseases has not been systematically elucidated or reviewed. Understanding the occurrence of ferroptosis in various pancreatic diseases after damage to the different cell types is crucial in determining disease progression, evaluating targeted therapies, and predicting disease prognosis. Herein, we summarize the research progress associated with ferroptosis in four common pancreatic diseases, namely acute pancreatitis, chronic pancreatitis, pancreatic ductal adenocarcinoma, and diabetes mellitus. Furthermore, the elucidation of ferroptosis in rare pancreatic diseases may provide sociological benefits in the future.© 2023. The Author(s) under exclusive licence to Japan Human Cell Society.