肝细胞癌（HCC）是全球死亡率最高的恶性肿瘤之一，易感性归因于遗传、生活方式和环境因素。淋巴毒素α（LTA）在淋巴细胞与基质细胞之间传递和激发对癌细胞的细胞毒作用中起着关键作用。尚未有关于LTA（c.179 C>A; p.Thr60Asn; rs1041981）基因多态性对HCC易感性的贡献的报告。本研究的主要目的是调查LTA（c.179 C>A; p.Thr60Asn; rs1041981）变异与埃及人群肝细胞癌风险之间的关联。 这项病例对照研究包括317名参与者（111例HCC患者和206名健康对照）。采用四引物扩增不耐受性突变系统聚合酶链反应（T-ARMS-PCR）技术评估了LTA（c.179 C>A; p.Thr60Asn; rs1041981）多态性。 LTA（c.179 C>A; p.Thr60Asn; rs1041981）变异的显性和隐性模型（CA+AA；AA）的频率在HCC患者与对照组之间存在统计学意义（p=0.01；p=0.007；分别）。LTA（c.179 C>A; p.Thr60Asn; rs1041981）变异的A等位基因在HCC患者中与对照组相比有显著差异（p＜0.001）。在埃及人群中，LTA（c.179 C>A; p.Thr60Asn; rs1041981）多态性独立地与肝细胞癌的风险增加相关。 ©2023. 作者（们）。

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide in terms of mortality, and susceptibility is attributed to genetic, lifestyle, and environmental factors. Lymphotoxin alpha (LTA) has a crucial role in communicating the lymphocytes with stromal cells and provoking cytotoxic effects on the cancer cells. There are no reports on the contribution of the LTA (c.179 C>A; p.Thr60Asn; rs1041981) gene polymorphism to HCC susceptibility. The main aim of this study is to investigate the association of LTA (c.179 C>A; p.Thr60Asn; rs1041981) variant with the HCC risk in the Egyptian population.This case-control study included 317 participants (111 HCC patients, and 206 healthy controls). The LTA (c.179 C>A; p.Thr60Asn; rs1041981) polymorphism was assessed by tetra-primer amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR) technique.The frequencies of the dominant and recessive models (CA + AA; AA) of the LTA (c.179 C>A; p.Thr60Asn; rs1041981) variant were statistically significant among HCC patients in comparison to controls (p = 0.01; p = 0.007; respectively). The A-allele of LTA (c.179 C>A; p.Thr60Asn; rs1041981) variant was statistically significant in HCC patients in comparison to controls (p ˂ 0.001).The LTA (c.179 C>A; p.Thr60Asn; rs1041981) polymorphism was independently associated with an increased risk for hepatocellular carcinoma in the Egyptian population.© 2023. The Author(s).