硅纳米线阵列通过诱导乳腺癌干细胞分化克服化疗耐药性。
Silicon nanowire array overcomes chemotherapeutic resistance by inducing the differentiation of breast cancer stem cells.
发表日期：2023 Mar 16
作者：
Xiaotong Wang, Sisi Liu, Wei Zhang, Haotong Peng, Miao Zhang, Yaping Li, Qi Guo, Wenjing Wang, Na Huang, LiYan Liu, Dandan Liu
来源：
Stem Cell Research & Therapy
摘要：
目前，传统癌症治疗策略受到癌症干细胞（CSCs）的存在所带来的化疗抵抗的严重挑战。分化治疗提出了一种针对CSC的新治疗策略。然而，目前对CSC分化的研究还很少。硅纳米线阵列（SiNWA）具有许多独特的性质，被认为是一种从生物技术到生物医学应用广泛的优秀材料。在这项研究中，我们报道硅纳米线阵列通过调节细胞形态将MCF-7源性乳腺癌干细胞（BCSCs）分化为非干细胞。在体外，分化后的BCSCs失去干性特征，因此变得对化疗药物敏感，最终导致BCSCs死亡。因此，这项工作提出了一种克服化疗抵抗的潜在方法。©2023 Wiley Periodicals LLC.
Currently, traditional cancer treatment strategies are greatly challenged by the existence of cancer stem cells (CSCs), which are root cause of chemotherapy resistance. Differentiation therapy presents a novel therapeutic strategy for CSC-targeted therapy. However, there are very few studies on the induction of CSCs differentiation so far. Silicon nanowire array (SiNWA) with many unique properties is considered to be an excellent material for various applications ranging from biotechnology to biomedical applications. In this study, we report the SiNWA differentiates MCF-7-derived breast CSCs (BCSCs) into non-CSCs by modulating the morphology of cells. In vitro, the differentiated BCSCs lose the stemness properties and thus become sensitive to chemotherapeutic drugs, eventually leading to the death of BCSCs. Therefore, this work suggests a potential approach for overcoming chemotherapeutic resistance.© 2023 Wiley Periodicals LLC.