烯丙基异硫氰酸酯（AITC）近年来被认为是有效的化疗和表观遗传调节因子，对AITC的化学预防性能和毒理学前景已经进行了多项调查。然而，它们的活性治疗相关性由于某些因素而受到限制，包括在典型的生理条件下不稳定以及由于水溶性较低而导致的低生物可用性。在本综述中，我们强调了AITC的化学预防属性，以及为了治疗癌症而与其分子机制和代谢命运相关的特性。此外，我们还强调了AITC作为抗癌药物的研究活性和不同类型癌症的传递策略。考虑到细胞间的相互作用，我们还揭示了AITCs的毒理学性质，以解决关于治疗发展中的评估问题。本综述通过涉及最新研究的各种当代方法，识别各种知识空白，并为新型AITC治疗方法的开发铺平道路。© 2023。作者（们）在Springer Science+Business Media，LLC的专属许可下，隶属于Springer Nature。

Allyl isothiocyanates (AITC) have gained recognition in recent years as effective chemotherapeutic and epigenetic modulators. The chemopreventive properties and toxicological perspectives of AITCs from the last few decades were taken into account by a number of investigations. Their active therapeutic relevance was hindered by a number of factors, including instability under typical physiological conditions and low bioavailability due to low aqueous solubility. In this review, we highlighted the chemopreventive attributes of AITC in relation to its molecular mechanisms and metabolic fate for cancer. Moreover, we emphasized on investigational anticancer activities and various strategies for delivery of AITC in different types of cancer. Considering cellular interactions, we shed light on the toxicological properties of AITCs to address further issues regarding their assessment in therapeutic development. This review identifies knowledge gaps with various contemporary approaches involving most recent studies and may pave the way for a better understanding for the development of novel AITC therapeutics.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.