硫化氢（H2S）是一种气体神经递质，可以被生物自我合成。随着研究的深入，内源性H2S在癌症的病理生理学机制越来越为人们所了解：（1）促进血管生成，（2）刺激细胞生物能，（3）促进迁移和增殖，从而入侵，（4）抑制细胞凋亡和（5）激活异常细胞周期。但是，通过外源性来源增加H2S水平表现出相反的趋势。这种现象可以通过H2S的钟形药理模型来解释，即，内源性（低浓度）H2S的产生促进肿瘤生长，而外源性（高浓度）H2S则抑制肿瘤生长。在这里，我们回顾内源性H2S合成和代谢对肿瘤进展的影响，总结H2S在肿瘤生长中的作用机制，并讨论H2S作为肿瘤治疗潜在靶点的可能性。© 2023 作者。细胞增殖由北京干细胞和再生医学研究所和约翰·威利和儿子有限公司出版。

Hydrogen sulphide (H2 S) is a gaseous neurotransmitter that can be self-synthesized by living organisms. With the deepening of research, the pathophysiological mechanisms of endogenous H2 S in cancer have been increasingly elucidated: (1) promote angiogenesis, (2) stimulate cell bioenergetics, (3) promote migration and proliferation thereby invasion, (4) inhibit apoptosis and (5) activate abnormal cell cycle. However, the increasing H2 S levels via exogenous sources show the opposite trend. This phenomenon can be explained by the bell-shaped pharmacological model of H2 S, that is, the production of endogenous (low concentration) H2 S promotes tumour growth while the exogenous (high concentration) H2 S inhibits tumour growth. Here, we review the impact of endogenous H2 S synthesis and metabolism on tumour progression, summarize the mechanism of action of H2 S in tumour growth, and discuss the possibility of H2 S as a potential target for tumour treatment.© 2023 The Authors. Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd.