现在，越来越多的公众和科学界对植物化学物在治疗人类疾病方面的应用感兴趣。尽管这个领域取得了显着的进展，但现有的癌症药物仍然面临一些障碍。例如，化疗可能会导致严重的不良反应、增加药物抗性和治疗失败。通过植物化学物质提供的天然物质为癌症治疗提供了创新的方法。生物活性天然化合物可以通过增加癌细胞对药物的敏感性来增强化疗。蜂胶等一些植物化学物质已被发现能够干扰癌细胞的生存能力。在蜂胶的所有成分中，咖啡酸苯乙酯（CAPE）（一种黄酮类）是受到最多研究的物质。它表现出广泛的治疗用途，包括抗肿瘤、抗微生物、抗病毒、抗炎、免疫调节、肝保护、神经保护和心脏保护等效应。在体外和体内进行的研究表明，CAPE可以特异性地靶向参与细胞死亡、细胞周期调节、血管生成和转移的基因。通过改变特定的信号转导通路，如NF-κB信号通路，CAPE能够限制人类癌细胞的增殖。本文总结了研究发现，重点关注CAPE在各种癌症模型中的多靶向分子和生物学意义，展示了其抗癌潜力。本文受版权保护。保留所有权利。

Nowadays, there is a lot of public and scientific interest in the use of phytochemicals in the treatment of human ailments. Existing cancer medicines still run across obstacles, despite significant advancements in the field. For instance, chemotherapy may result in severe adverse effects, increased drug resistance, and treatment failure. Natural substances that are phytochemically derived provide innovative approaches as potent therapeutic molecules for the treatment of cancer. Bioactive natural compounds may enhance chemotherapy for cancer by increasing the sensitivity of cancer cells to medicines. Propolis has been found to interfere with the viability of cancer cells, among other phytochemicals. Of all the components that make up propolis, caffeic acid phenethyl ester (CAPE) (a flavonoid) has been the subject of the most research. It demonstrates a broad spectrum of therapeutic uses, including antitumor, antimicrobial, antiviral, anti-inflammatory, immunomodulatory, hepatoprotective, neuroprotective, and cardioprotective effects. Studies conducted both in vitro and in vivo have demonstrated that CAPE specifically targets genes involved in cell death, cell cycle regulation, angiogenesis, and metastasis. By altering specific signaling cascades, such as the NF-κB signaling pathway, CAPE is able to limit the proliferation of human cancer cells. This review highlights the research findings demonstrating the anticancer potential of CAPE with a focus on multitargeted molecular and biological implications in various cancer model.This article is protected by copyright. All rights reserved.