低密度脂蛋白受体相关蛋白11 (LRP11) 参与了多种肿瘤的进展，然而其在宫颈癌中的作用仍不确定。原始肿瘤数据从癌症基因组图谱和基因型组织表达数据库中下载。评估了正常组织、肿瘤组织和癌旁组织中 LRP11 的表达。此外，我们还研究了 LRP11 的遗传变异、预后价值和基因功能，并深入评估了 LRP11 与多种肿瘤免疫的相互作用。最后，我们开展了关于 LRP11 与抗肿瘤药物抗性关联的研究。LRP11 在宫颈癌和多种肿瘤中高表达并作为一种危险预测因子。富集分析表明 LRP11 参与了多种恶性肿瘤通路。我们的研究还指出了 LRP11 与肿瘤免疫微环境之间的独特作用。表达 LRP11 高的患者的肿瘤免疫微环境缺乏大部分免疫细胞，表明存在免疫沙漠肿瘤微环境。最后的抗药性分析表明，表达 LRP11 高的患者可能与多种抗肿瘤药物的抵抗有关。LRP11 在宫颈癌和泛癌中是潜在的致癌基因和预后标志物。表达 LRP11 高的患者可能存在免疫沙漠肿瘤微环境。版权所有 ©2023 作者。由 Wolters Kluwer Health, Inc. 发布。

Low density lipoprotein receptor-related protein 11 (LRP11) was involved in the progression of several tumors. However, its role in cervical cancer still remains uncertain.The original tumor data was downloaded from the Cancer Genome Atlas and genotype-tissue expression databases. The expression of LRP11 in normal tissues, tumor tissues and adjacent tissues were evaluated. In addition, we also explored the genetic alteration, prognostic value, and gene function of LRP11. We deeply assessed the interaction between LRP11 and tumor immunity at the pan-cancer level. Finally, research on the association between LRP11 and the resistance of anti-tumor drugs was carried out.LRP11 was highly expressed and played a risk prognostic factor in cervical cancer and a variety of tumors. Enrichment analysis revealed that LRP11 was involved in multiple tumor malignant pathways. Our research also pointed out the unique role between LRP11 and tumor immune microenvironment. The tumor immune microenvironment of patients with high expression of LRP11 are lack of most immune cells, indicating a immune desert tumor microenvironment. The final drug resistant analysis suggested that patients with high expression of LRP11 may be related to the resistance of many anti-tumor drugs.LRP11 was a potential oncogene and prognostic marker in cervical cancer and pan-cancer. Patients with high LRP11 expression may have immune desert tumor microenvironment.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.