慢性炎症在许多威胁生命的慢性疾病（包括癌症）的病因病理学中起着重要作用。目前，炎症、免疫和癌症之间的关系被广泛接受；但是，调解这种关系的许多机制仍未确定，并且这些标记的临床意义尚不清楚。本研究旨在调查中性粒细胞-淋巴细胞比（NLR）和平均血小板体积（MPV）指示肺癌转移存在的潜力。这是一项回顾性横断面研究，评估了2019年1月至2020年2月期间入住转诊医院姑息治疗病房的任何病理类型的肺癌患者。记录了患者特征、远隔器官转移、治疗、NLR和MPV值。将患者分为存在或不存在转移组。比较字符、NLR、MPV值。共纳入126名患者。患者的平均年龄为61.17±9.4岁，7.9%（n = 10）为女性。有过化疗史的患者占47%（n = 60），远隔器官转移出现在38.9%（n = 49）的患者中。49例有远隔转移的患者的平均MPV值为8.34±0.8 fL。发现有转移的患者的MPV值显著高于没有转移的患者（P = .010）。两组之间的NLR值没有显著差异（P = .920）。肺癌患者有转移的MPV值较高。MPV可以是有效的和最易得到的测试，用于预测肺癌患者的转移情况，而不考虑病理类型。版权所有© 2023作者。 Wolters Kluwer Health，Inc.出版。

Chronic inflammation plays an important role in the etiopathogenesis of many life-threatening chronic diseases, including cancer. Currently, the relationship between inflammation, native immunity and cancer is widely accepted; however, many of the mechanisms mediating this relationship remain undetermined and the clinical significance of these markers is unclear. The purpose of this study was to investigate the potential of neutrophil-lymphocyte ratio (NLR) and mean platelet volume (MPV) to indicate the existence of metastasis in lung cancer. This retrospective cross-sectional study evaluated patients with lung cancer of any pathological type who was admitted to the Palliative Care Unit of the referral hospital in the region between January 2019 and February 2020. Patient characteristics, distant organ metastasis, treatments, NLR and MPV values were noted. Patients were grouped as with or without metastasis. Characters, NLR, MPV values were compared. One hundred twenty-six patients were included. The mean age of the patients was 61.17 ± 9.4 years and 7.9% (n = 10) were female. The patients with a history of chemotherapy were 47% (n = 60) and distant organ metastases were present in 38.9% (n = 49) of the patients. The mean MPV value of 49 patients with distant metastasis was 8.34 ± 0.8 fL. MPV values of those with metastasis were found to be significantly higher than those without (P = .010). There was no significant difference in NLR values between groups (P = .920). Lung cancer patients with metastasis were found with higher MPV values. MPV can be effective and most accessible test in prediction of metastasis in lung cancer patients regardless of the pathological type.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.