透明细胞肾细胞癌（ccRCC）是肾细胞癌的最常见类型。免疫球蛋白FcγRIIa受体（FCGR2A）已被牵涉到各种癌症，然而，在ccRCC上的作用尚未得到很好的研究。本研究招募了151名ccRCC患者。进行Cox比例风险回归分析以计算FCGR2A表达和肿瘤特征的危险比。通过苏木精-伊红染色分析肿瘤组织切片中与ccRCC相关的病理变化。使用免疫组织化学和免疫荧光染色检测组织切片中FCGR2A的蛋白质表达。通过生物过程神经网络和支持向量机分析FCGR2A表达与ccRCC患者总生存期（OS）之间的相关性。 FCGR2A的表达与肿瘤TNM、ccRCC家族史和Fuhrman分期显著相关。肿瘤组织中FCGR2A高表达的患者比低中等FCGR2A表达的患者生存期较短。接收者操作特征曲线显示，FCGR2A可用作ccRCC的敏感和特定的生物标记。Western blotting显示FCGR2A在ccRCC组织中的表达水平较高。生物过程神经网络和支持向量机拟合显示FCGR2A与ccRCC患者生存时间之间的R2分别为0.8429和0.7669。FCGR2A在ccRCC中高表达，FCGR2A的高表达与ccRCC的较差OS相关。版权所有© 2023作者。 Wolters Kluwer Health，Inc. 发布

Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cell carcinoma. Immunoglobulin FcγRIIa receptor (FCGR2A) has been implicated in various cancers, however, its role on ccRCC is not well studied. A total of 151 patients with ccRCC were recruited for the study. Cox proportional hazards regression analysis was performed to calculate the hazard radios of FCGR2A expression and tumor characteristics. Pathological changes associated with ccRCC in tumor tissue sections were analyzed by hematoxylin-eosin staining. Immunohistochemical and immunofluorescence staining were used to detect the protein expression of FCGR2A in the tissue sections. Correlation between the expression of FCGR2A and the overall survival (OS) of ccRCC patients was analyzed by biological process neural network and support vector machine. The expression of FCGR2A was significantly correlated with the TNM of tumor, family history of ccRCC and Fuhrman stage of ccRCC. Patients with high FCGR2A expression in the tumor tissue, had poorer OS than the patients with low and moderate FCGR2A expression. The Receiver operating characteristic curve showed that FCGR2A can be used as a sensitive and specific biomarker for the diagnosis of ccRCC. Western blotting revealed that the FCGR2A was expressed at higher levels in the ccRCC tissues. Biological process neural network and support vector machine fitting showed that the R2 between FCGR2A and survival time of ccRCC patients was 0.8429 and 0.7669, respectively. FCGR2A is highly expressed in ccRCC, higher expression of FCGR2A is associated with poorer OS of ccRCC.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.