组织再生和手术切除后的肿瘤细胞杀灭是实现有效肿瘤治疗的两个关键因素。本研究构建了一种具有肿瘤治疗和组织修复功能的可植入系统。利用具有Fenton催化活性的丹宁酸（TA）/Fe3+纳米颗粒加载了GSH抑制剂BSO药物（BTF），作为治疗因子实现了放大的化学动力学肿瘤治疗。同时，使用负载血管内皮生长因子（VEGF）的生物活性玻璃（BG）纤维作为具有组织修复功能的药物载体矩阵（BGV）。然后，将BTF纳米颗粒固定在BGV纤维表面，从而得到BGV@BTF复合纤维。在肿瘤酸性条件下，BTF纳米颗粒可以从复合纤维中释放出来，并被肿瘤细胞吸收。在GSH抑制效应下，BTF纳米颗粒可以通过TA的Fe3+还原性实现高氧化应激和随后的细胞死亡。此外，BG纤维和VEGF都可以促进组织再生和加速术后创面愈合。本研究中肿瘤生长的同时抑制和组织修复的促进的成果在术后肿瘤治疗和康复领域具有启发意义。

Tissue regeneration and tumor cell killing after surgical resection are the two keys to achieving effective tumor therapy. In this study, an implantable system with combined functions of tumor therapy and tissue repair was constructed. Tannic acid (TA)/Fe3+ nanoparticles with Fenton catalytic activity were loaded with GSH inhibitor BSO drug (BTF), and acted as the therapeutic factor to realize amplified chemodynamic tumor treatment. Bioactive glass (BG) fibers loaded with vascular endothelial growth factor (VEGF) were used as the drug carrier matrix with tissue repair function (BGV). Then the BGV@BTF composite fibers were obtained by anchoring BTF nanoparticles on the surface of BGV fibers. Under tumorous acidic conditions, BTF nanoparticles can be released from the composite fibers, and taken up by tumor cells. Facilitated by BSO with the GSH suppression effect and TA with Fe3+ reducing properties, BTF nanoparticles can realize high oxidative stress in tumor cells and subsequent cell death. In addition, BG fibers and VEGF can both promote tissue regeneration and accelerate postoperative wound healing. The simultaneous suppression of tumor growth and promotion of tissue repair in this work is inspiring in the field of postoperative tumor treatment and recovery.