评估母体血清炎性标志物在宫内生长受限（IUGR）妊娠中的变化。50名健康孕妇和50名被诊断为IUGR的患者被纳入。分娩前测量了母体血清高灵敏度C-反应蛋白（hsCRP）、红细胞沉降率（ESR）、肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-6和IL-10水平，并评估了新生儿的结果。IUGR组的出生体重、Apgar评分和脐血气pH均较低（分别为p＜0.001、p＜0.001、p＜0.001和p=0.006）。虽然ESR、hsCRP、IL-6和TNF-α水平较高，但IUGR组的IL-10水平较低（分别为p＜0.001、p=0.033、p＜0.001、p=0.004和p＜0.001）。随着ESR、hsCRP和IL-6水平的升高，出生体重、Apgar评分和脐血气pH均下降（分别为p＜0.001、p＜0.001、p＜0.001、p＜0.001、p=0.02、p=0.002、p=0.001、p=0.03、p＜0.001、p＜0.001、p＜0.001和p=0.02）。随着TNF-α水平的增加，只有出生体重和1分钟的Apgar评分下降（分别为p=0.006和p=0.048）。随着IL-10水平的降低，出生体重、Apgar评分和脐血气pH均下降（所有的p＜0.001）。IL-6（＞3.2 pg/mL）具有100％的敏感度、100％的特异度、100％的阳性预测值和100％的阴性预测值。虽然IUGR患者的出生体重、Apgar评分和脐血pH降低，但ESR、hsCRP、IL-6和TNF-α水平升高。这些标志物的联合测量可用于IUGR的诊断。

To evaluate maternal serum inflammatory marker changes in intrauterine growth restriction (IUGR) pregnancies.50 healthy pregnant women and 50 patients diagnosed with IUGR were enrolled. Maternal serum high sensitivity C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-10 levels were measured before delivery and neonatal outcomes were evaluated.Birth weight, Apgar scores, and cord blood gas pH were lower in the IUGR group (p<0.001, p<0.001, p<0.001 and p=0.006, respectively). While the levels of ESR, hsCRP, IL-6, and TNF-α were higher, the IL-10 level was found to be lower in the IUGR group (p<0.001, p=0.033, p<0.001, p=0.004 and p<0.001, respectively). As ESR, hsCRP, and IL-6 levels increased, birth weight, Apgar scores, and cord blood gas pH decreased (p<0.001, p<0.001, p<0.001, p<0.001, p=0.02, p=0.002, p=0.001, p=0.03, p<0.001, p<0.001, p<0.001 and p=0.02, respectively). As TNF-α level increased, only birth weight and Apgar score at the 1st minute decreased (p=0.006 and p=0.048, respectively). As IL-10 level decreased, birth weight, Apgar scores, and cord blood gas pH decreased (p<0.001 for all). IL-6 (>3.2 pg/ml) had a sensitivity of 100%, specificity of 100%, PPV of 100% and NPV of 100%.While birth weight, Apgar score and cord blood pH decreased in IUGR cases, ESR, hsCRP, IL-6 and TNF-α levels increased. Combined measurement of these markers can be used for the diagnosis of IUGR.