循环肿瘤细胞（CTCs）的稀有性和血液成分的复杂性对于在血液中高效分离CTCs来说是巨大挑战。共存物质可能会通过粘附到材料表面的结合位点来干扰CTCs的检测，导致生物标记物捕获在血液中的准确度降低。在此，我们通过紫外光引发，在石英板上移植1H，1H，2H，2H-庚十七氟十二烷基丙烯酸酯聚合物和3-丙烯酰胺基苯硼酸聚合物刷子，然后通过苯硼酸基团和多巴酸基团之间的可逆咪唑酚硼酸化学反应，在材料表面移植癌细胞结合肽，实现CTCs的高效捕获和非破坏性糖应答释放所需细胞。图案化的动态生物活性润滑剂注入表面（PDBLIS）进一步展现了对CTCs的捕获效率和对非特定细胞和血液成分的更有效的抗粘附性能的改善。此外，PDBLIS可以有效地从模拟癌症患者血样中捕获罕见癌细胞。我们预计，我们提出的策略将在复杂的涉及各种肿瘤的生物流体的进一步临床诊断中得到应用，并展示未来液体活检的良好前景和潜力。

The rarity of circulating tumor cells (CTCs) and the complexity of blood components present major challenges for the efficient isolation of CTCs in blood. The coexisting matters could interfere with the detection of CTCs by adhering to the binding sites on the material surface, leading to the reduced accuracy of biomarker capture in blood. Herein, we developed dynamic bioactive lubricant-infused slippery surfaces by grafting the 1H,1H,2H,2H-heptadecafluorodecyl acrylate polymer and 3-acrylamidophenylboronic acid polymer brushes on quartz plates by UV light-initiated and then grafted cancer cell-binding peptides via reversible catechol-boronate chemistry between phenylboronic acid groups and 3,4-dihydroxy-l-phenylalanine groups of peptides for high-efficient capture of CTCs and nondestructive release of the desired cells in sugar response. Patterned dynamic bioactive lubricant-infused surfaces (PDBLISs) further exhibited the improved capture efficiency of CTCs and more effective antifouling properties for nonspecific cells and blood components. Moreover, the PDBLIS can efficiently capture rare cancer cells from the mimic of cancer patient's blood samples. We anticipate that the strategy we proposed would be used in further clinical diagnosis of complicated biofluids related to a variety of tumors and exhibit good prospects and potential in future liquid biopsies.