非常规蛋白质分泌（UPS）是一种重要机制，控制缺乏信号肽的胞质蛋白的定位，并涉及炎症，神经退行性疾病和癌症。在免疫细胞上的几项研究已经证明了UPS的机制。在癌症中，已描述了几种胞质蛋白的活性分泌，包括PKCδ和核仁蛋白。此外，我们最近证明内质网的膜蛋白之一延伸同型半胱氨酸 1 在肝癌细胞中在UPS中发挥了关键作用。重要的是，癌细胞中的UPS显示出明显不同于先前已知的UPS的特征，因此，我们将它们归类为癌症相关UPS（CUPS）。在本文中，我们提供UPS机制的概述，并讨论命名癌症特异性UPS为CUPS的过程。

Unconventional protein secretion (UPS) is a crucial mechanism controlling the localization of cytosolic proteins lacking signal peptides and is implicated in inflammation, neurodegenerative diseases, and cancer. Several previous studies on immune cells have demonstrated the mechanisms of UPS. In cancer, the active secretion of several cytosolic proteins, including PKCδ and nucleolin, has been described. Moreover, we have recently demonstrated that extended synaptotagmin 1, one of the membrane proteins of the endoplasmic reticulum, plays a critical role in UPS in liver cancer cells. Importantly, UPS in cancer cells shows characteristics that are markedly different from those of the previously known UPS, and therefore, we categorize them as cancer-related UPS (CUPS). In this article, we provide an overview of UPS mechanisms and discuss the process that leads to the naming of cancer-specific UPS as CUPS.