卵巢癌是影响女性生殖器官的最常见的恶性肿瘤之一。CD147 (BSG) 和CD98hc (SLC3A2) 是一个促进肿瘤细胞增殖、转移、代谢和细胞周期的致癌基因，它们共同形成CD98hc-CD147复合物。目前CD98hc-CD147在卵巢癌中的作用尚不清楚。我们利用TCGA和ICGC数据库分析了CD147和CD98hc在卵巢癌中的表达和预后价值，并使用TIMER数据库分析了CD147和CD98hc对肿瘤免疫应答的影响。结果表明，在正常组织中CD98hc的表达水平高于原发肿瘤组织，而CD147在原发肿瘤组织中的表达水平高于正常组织。CD98hc表达与中性粒细胞和树突状细胞水平显著相关。CD147和CD98hc与DNA修复、细胞周期和DNA复制有关。因此，CD98hc-CD147复合物可能是卵巢癌治疗的一个治疗靶点。

Ovarian cancer is one of the most common malignant tumours affecting the female reproductive organs. CD147 (BSG) and CD98hc (SLC3A2) are oncogenes that form the CD98hc-CD147 complex, which regulates the proliferation, metastasis, metabolism, and cell cycle of cancer cells. The roles of the CD98hc-CD147 complex in ovarian cancer remain unclear. We analysed the expression and prognostic value of CD147 and CD98hc in ovarian cancer using the TCGA and ICGC databases. The effect of CD147 and CD98hc on the tumour immune response was analysed using the TIMER database. CD98hc was more highly expressed in normal tissues than primary tumour tissues, while CD147 was more highly expressed in primary tumour tissues than normal tissues. CD98hc expression was significantly associated with neutrophil and dendritic cell levels. CD147 and CD98hc were correlated with DNA repair, the cell cycle, and DNA replication. The CD98hc-CD147 complex could serve as a target for ovarian cancer treatment.