Organoids 是人体生理的体外模型。神经模型需要评估单个细胞和网络的功能活动，并通过微电极阵列通常进行测量。器官小体的特征与现有的体内或体外微电极阵列相冲突。受可植入网状电子和器官小体在聚合物支架上生长的启示，我们制造了悬挂的吊床状网状微电极阵列，用于神经小体。我们已经证明了在这些网状结构上包裹小体的生长并在网状结构上培养小体长达一年。此外，我们还展示了对一个小体的体积范围内自发电活性的原理性记录。我们的概念为体外三维电活性组织的新型微电极阵列提供了可能。 版权©2023 Elsevier B.V.版权所有。

Organoids are emerging in vitro models of human physiology. Neural models require the evaluation of functional activity of single cells and networks, which is commonly measured by microelectrode arrays. The characteristics of organoids clash with existing in vitro or in vivo microelectrode arrays. With inspiration from implantable mesh electronics and growth of organoids on polymer scaffolds, we fabricated suspended hammock-like mesh microelectrode arrays for neural organoids. We have demonstrated the growth of organoids enveloping these meshes and the culture of organoids on meshes for up to one year. Furthermore, we present proof-of-principle recordings of spontaneous electrical activity across the volume of an organoid. Our concept enables a new class of microelectrode arrays for in vitro models of three-dimensional electrically active tissue.Copyright © 2023 Elsevier B.V. All rights reserved.