一名女性经过单倍体脐带血移植后，HIV-1处于缓解状态并有可能治愈。
HIV-1 remission and possible cure in a woman after haplo-cord blood transplant.
发表日期：2023 Mar 16
作者：
Jingmei Hsu, Koen Van Besien, Marshall J Glesby, Savita Pahwa, Anne Coletti, Meredith G Warshaw, Larry Petz, Theodore B Moore, Ya Hui Chen, Suresh Pallikkuth, Adit Dhummakupt, Ruth Cortado, Amanda Golner, Frederic Bone, Maria Baldo, Marcie Riches, John W Mellors, Nicole H Tobin, Renee Browning, Deborah Persaud, Yvonne Bryson,
来源：
CELL
摘要：
以前，通过CCR5Δ32纯合子（CCR5Δ32/Δ32）异基因成人间充质干细胞移植，治愈了两名HIV-1患者。我们报告了一位混血女性，她接受了CCR5Δ32/Δ32半相合脐带移植（脐带血细胞结合成人半相合干细胞），治疗急性髓细胞白血病（AML），首次出现缓解和可能的HIV-1治愈。移植后第14周的外周血嵌合率为100%CCR5Δ32/Δ32脐带血，并在4.8年的随访中持续存在。免疫重建与（1）可检测的可复制HIV-1库存的丧失，（2）失去HIV-1特异性免疫反应，（3）体外对X4和R5实验室变异体的耐受性，包括移植前的自体潜伏库分离物，以及（4）从移植后37个月开始的18个月的HIV-1控制程度相一致。CCR5Δ32/Δ32半相合脐带移植为一位多样化祖先的、患有HIV-1的、需要干细胞移植治疗急性白血病的患者实现了缓解和可能的HIV-1治愈。
版权所有 © 2023作者。由Elsevier Inc.出版。保留所有权利。
Previously, two men were cured of HIV-1 through CCR5Δ32 homozygous (CCR5Δ32/Δ32) allogeneic adult stem cell transplant. We report the first remission and possible HIV-1 cure in a mixed-race woman who received a CCR5Δ32/Δ32 haplo-cord transplant (cord blood cells combined with haploidentical stem cells from an adult) to treat acute myeloid leukemia (AML). Peripheral blood chimerism was 100% CCR5Δ32/Δ32 cord blood by week 14 post-transplant and persisted through 4.8 years of follow-up. Immune reconstitution was associated with (1) loss of detectable replication-competent HIV-1 reservoirs, (2) loss of HIV-1-specific immune responses, (3) in vitro resistance to X4 and R5 laboratory variants, including pre-transplant autologous latent reservoir isolates, and (4) 18 months of HIV-1 control with aviremia, off antiretroviral therapy, starting at 37 months post-transplant. CCR5Δ32/Δ32 haplo-cord transplant achieved remission and a possible HIV-1 cure for a person of diverse ancestry, living with HIV-1, who required a stem cell transplant for acute leukemia.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.